Genetics of the central MHC

Current Opinion in Immunology
Georges Hauptmann, Seiamak Bahram

Abstract

The MHC, primarily known for its antigen-presenting class I and II molecules, harbours, within a central segment of less than 1 Mb, a dense collection of genes involved in various biological functions. Although MHC I and MHC II are principal players of adaptive immunity, several loci within this central (still called class III) MHC region encode members of the innate immune system. These include the long known factors of the complement system--potentially inhibitory and triggering natural killer receptors as well as stress proteins. Whether this physical proximity is fortuitous or functionally advantageous is an important question for the future of MHC genetics.

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Citations

Dec 3, 2010·Rheumatology International·Vidya S LimayePeter Roberts-Thomson
Sep 14, 2011·Current Diabetes Reports·Janelle A Noble, Ana M Valdes
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Apr 1, 2013·Molecular Informatics·Christian P KochGisbert Schneider
Dec 11, 2019·Current Diabetes Reports·Rebecca C WyattSarah J Richardson

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