Genetics of uveal melanoma and cutaneous melanoma: two of a kind?

Dermatology Research and Practice
Thomas van den BoschAnnelies de Klein

Abstract

Cutaneous melanoma and uveal melanoma both derive from melanocytes but show remarkable differences in tumorigenesis, mode of metastatic spread, genetic alterations, and therapeutic response. In this review we discuss the differences and similarities along with the genetic research techniques available and the contribution to our current understanding of melanoma. The several chromosomal aberrations already identified prove to be very strong predictors of decreased survival in CM and UM patients. Especially in UM, where the overall risk of metastasis is high (45%), genetic research might aid clinicians in selecting high-risk patients for future systemic adjuvant therapies.

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Methods Mentioned

BETA
biopsy
chips
array technology
chromosomal aberration
chromosomal aberrations

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