Genetics/epigenetics/allergy: The gun is loaded … but what pulls the trigger?

Allergy and Asthma Proceedings
Joseph A Bellanti

Abstract

Background: The allergic diseases comprise a group of chronic inflammatory conditions that display a broad spectrum of clinical manifestations primarily mediated by immunoglobulin E (IgE). The prevalence and severity of these IgE-mediated allergic disorders have increased dramatically over the past few decades and are becoming a global health problem. Although genetics plays an important role in determining who develops these atopic disorders, genetics alone cannot fully explain this rapid growth. Results of numerous studies have indicated that epigenetics plays a major pathogenetic role by superimposing its effects above the DNA primal genetic molecule through interactions with and between various susceptibility genes, immunologic influences, and environmental factors. Objective: In this article, the importance and relationships of genetics and epigenetics to an understanding of the immune system in health and in disease were reviewed together with the principles and mechanisms that underlie these entities and which relate to clinical allergy practice. A specific focus of the article was directed to the recent recognition that the IgE-driven atopic disorders are driven by aberrant immune responses in which CD25+ Forkhead box P...Continue Reading

Citations

Nov 16, 2019·Pediatric Research·Joseph A Bellanti
Nov 17, 2019·Genes·Andrée-Anne Hudon Thibeault, Catherine Laprise
May 9, 2021·Biochemical Genetics·Alexandra S KarunasElza K Khusnutdinova

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