Genic alterations in oral and head and neck squamous cell carcinomas: analysis of international literature

Pathologie-biologie
H RaybaudR A Monteil

Abstract

The development of oral and head and neck squamous cell carcinomas occurs in relation with multiple events including mainly: loss of cycle cell control, evasion from apoptosis, telomerase reactivation. Complex interactions between a set of molecules, cell cycle proteins, tumour suppressor genes, oncogenes and the telomerase, occur in the multiple step process of carcinogenesis. The 2 main ways of control of the cell cycle rely on 2 tumour suppressor genes: the P53 gene and the retinoblastoma gene or RB gene. One of the regulation pathways or the 2 regulation pathways are disabled during the development of oral and head and neck squamous cell carcinomas. Most of the time, the inactivation of the P53 pathway results from a loss of function of the p53 protein, secondary to mutation and/or deletion of the P53 gene; It may also result of the amplification of the MDM2 gene and of the inactivation of the arf protein. The RB pathway leads to cell proliferation by loss of the p16 protein, by amplification of the cyclin D1 gene and less frequently by mutation of the RB gene or loss of the retinoblastoma protein. In India and South-East Asia, the activation of RAS and MYC oncogenes appears to be related with the presence of specific carci...Continue Reading

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Citations

Oct 13, 2012·Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology·Francesca PrignanoPiero Campolmi
Apr 9, 2005·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·A MartínezM I Rudolph
Feb 27, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Anupam Mishra, Rohit Meherotra

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