Genipin-crosslinked carboxymethyl chitosan nanogel for lung-targeted delivery of isoniazid and rifampin

Carbohydrate Polymers
Ting WuXiang Cai

Abstract

Lung-targeted genipin-crosslinked deacetylated chitosan (GEN-CS)/isoniazid (INH)/rifampin (RMP) nanogel particles (NGPs) were prepared as a treatment for tuberculosis caused by multidrug-resistant Mycobacterium tuberculosis (MTB) to surmount the undesirable side effects and decrease the cytotoxicity of INH and RMP when being against MTB. The size, morphology, in vitro release property, long-term antibacterial performance, stability, in vitro cytotoxicity, in vivo toxicity, and in vivo release property of GEN-CS/INH/RMP NGPs inhalation powder were investigated. The results showed that the GEN-CS/INH/RMP NGPs inhalation powder exhibited extended antibacterial activity because of its long-term release of INH and RMP. A simplex GEN-CS/INH/RMP NGPs pulmonary dose led to the therapeutic drug concentration of 40%-60% in lung and other organs (<5%) for 24 h. Furthermore, this GEN-CS/INH/RMP NGPs lyophilized inhalation powder displayed lung-targeted property and lower in vivo toxicity. These results suggested that this GEN-CS/INH/RMP NGPs inhalation powder would be a more useful dosage form than separate dose of INH or RMP for MTB.

Citations

Sep 26, 2019·Expert Review of Medical Devices·Flavio De MaioMassimiliano Papi
Jan 25, 2020·Nanomaterials·Jorge F Pontes, Ana Grenha
Dec 5, 2018·Journal of Biomaterials Applications·Gangquan ChenChao Zhang
Oct 27, 2020·Nanomedicine·Filippo PinelliFilippo Rossi
Dec 19, 2020·International Journal of Biological Macromolecules·Sheersha Pramanik, Vaishnavi Sali
Apr 16, 2021·International Journal of Biological Macromolecules·Trong-Ming DonEr-Yuan Chuang
Apr 27, 2021·Bioactive Materials·Damla KeskinPatrick van Rijn
Aug 19, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Elmar Damasceno JuniorDjalma Ribeiro da Silva

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