Genipin-crosslinked human serum albumin coating using a tannic acid layer for enhanced oral administration of curcumin in the treatment of ulcerative colitis

Food Chemistry
Ruifeng LuoFei Gao

Abstract

Curcumin (CUR) is a promising edible phytochemical compound with ideal ulcerative colitis (UC) treatment activity; however, it is characteristically instable in the digestive tract and has a short retention time in colon. Therefore, we designed and fabricated an oral food-grade nanocarrier composed of tannic acid (TA)-coated, Genipin (Gnp)-crosslinked human serum albumin (HSA) to encapsulate CUR (TA/CUR-NPs). The resulting CUR nanoparticles (NPs) were about 220 nm and -28.8 mV. With the assistance of TA layer and Gnp-crosslinking, the entire nano-scaled system effectively delayed CUR release in simulated gastric fluid, prolonged its colon adhesion and increased its uptake in Caco-2 cells. As expected, TA/CUR-NPs oral administration significantly alleviated colitis symptoms in DSS-treated mice when compared with controls by inhibiting the TLR4-linked NF-κB signaling pathway. Collectively, this study indicates that we have developed a convenient, eco-friendly, nano-scaled vehicle for oral delivery of CUR with anti-UC benefit.

Citations

Aug 11, 2020·Expert Review of Gastroenterology & Hepatology·Ricardo de Alvares GoulartElen Landgraf Guiguer
Feb 1, 2021·Colloids and Surfaces. B, Biointerfaces·Ozgur Tarhan, Maria Julia Spotti
May 7, 2021·International Journal of Pharmaceutics·Yuanyuan ChenJian Ming
Jun 5, 2021·ACS Applied Materials & Interfaces·Moustafa T MabroukJonathan F Lovell
Jul 20, 2021·Advanced Drug Delivery Reviews·Zhejie ChenYitao Wang
Sep 14, 2021·Frontiers in Bioengineering and Biotechnology·Meisi LinJinming Zhang

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