Genistein, a soy phytoestrogen, upregulates the expression of human endothelial nitric oxide synthase and lowers blood pressure in spontaneously hypertensive rats.

The Journal of Nutrition
Hongwei Si, Dongmin Liu

Abstract

Genistein, a soy phytoestrogen, may improve vascular function, but the mechanism of this effect is unclear. Endothelial-derived nitric oxide (NO) is a key regulator of vascular tone and atherogenesis. Previous studies have established that estrogen can act directly on vascular endothelial cells (EC) to enhance NO synthesis through genomic stimulation of endothelial NO synthase (eNOS) expression. However, it is unknown whether genistein has a similar effect. We therefore investigated whether genistein directly regulates NO synthesis in primary human aortic EC (HAEC) and human umbilical vein EC (HUVEC). Genistein, at physiologically achievable concentrations in individuals consuming soy products, enhanced the expression of eNOS and subsequently elevated NO synthesis in both HAEC and HUVEC, with 1-10 micromol/L genistein inducing the maximal effects. However, the effects of genistein on eNOS and NO were not mediated by activation of estrogen signaling or inhibition of tyrosine kinases, 2 known biological actions of genistein. Genistein (1-10 micromol/L) increased eNOS gene expression (1.8- to 2.6-fold of control) and significantly increased eNOS promoter activity of the human eNOS gene in HAEC and HUVEC, suggesting that genistein ...Continue Reading

References

Mar 1, 1981·Circulation Research·N C Trippodo, E D Frohlich
Feb 14, 1995·Proceedings of the National Academy of Sciences of the United States of America·H E von der LeyenV J Dzau
Sep 1, 1995·The Journal of Nutrition·X XuS Hendrich
Jan 1, 1997·Free Radical Research·M B Ruiz-LarreaC A Rice-Evans
Jan 23, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·P J NestelM Abbey
Mar 10, 1998·Proceedings of the Society for Experimental Biology and Medicine·T B ClarksonJ M Cline
Jun 3, 1998·Arquivos brasileiros de cardiologia·G Iturry-YamamotoP D Picon
Dec 16, 1998·The American Journal of Clinical Nutrition·M S AnthonyJ K Williams
Jan 27, 1999·Methods in Enzymology·H HiguchiI Kurose
Jul 19, 2000·Proceedings of the National Academy of Sciences of the United States of America·M SasakiT M Dawson
Feb 7, 2001·The American Journal of Clinical Nutrition·K E WangenM S Kurzer
Mar 14, 2001·American Journal of Physiology. Cell Physiology·A W Harmon, J B Harp
Apr 4, 2001·The Journal of Nutrition·D Goodman-Gruen, D Kritz-Silverstein
Sep 25, 2001·Journal of Applied Physiology·G C Sieck
Oct 10, 2002·Endocrine Reviews·Ken L Chambliss, Philip W Shaul
Jan 7, 2003·The Journal of Nutrition·Silvana M L Turbino-RibeiroMaria Lucia Pedrosa
May 3, 2003·The American Journal of Medicine·Francesco SquadritoGiovanni Squadrito
Jun 27, 2003·The Journal of Clinical Hypertension·Angelo Scuteri, Luigi Ferrucci
Aug 9, 2003·The New England Journal of Medicine·JoAnn E MansonUNKNOWN Women's Health Initiative Investigators
Aug 26, 2003·The American Journal of Clinical Nutrition·Kenneth D R Setchell, Eva Lydeking-Olsen
Nov 12, 2003·Proceedings of the National Academy of Sciences of the United States of America·Daigo Sumi, Louis J Ignarro
Dec 24, 2003·Thrombosis and Haemostasis·Hidesaku AsakuraShinji Nakao
Aug 24, 2004·Current Medicinal Chemistry. Cardiovascular and Hematological Agents·Domenica AltavillaFrancesco Squadrito
Dec 15, 2004·Cardiology in Review·Denise ParkWilliam H Frishman

❮ Previous
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Citations

Aug 1, 2010·Nutrients·Davide GrassiClaudio Ferri
May 18, 2013·Climacteric : the Journal of the International Menopause Society·L Al-NakkashT L Broderick
Oct 16, 2019·Journal of Cardiovascular Pharmacology·Kazuo Yamagata, Yukio Yamori
Nov 3, 2012·The British Journal of Nutrition·Nallasamy Palanisamy, Anuradha C Venkataraman
Apr 29, 2011·The Journal of Nutrition·Hongwei SiDongmin Liu
Jun 6, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Shuhao YuShi-Bing Su
Apr 22, 2017·Free Radical Research·Khalil Ali AhmadDing Qilong
Dec 20, 2018·Journal of Cellular Physiology·Mohammadhossein HassanshahiCory J Xian
Sep 27, 2008·Journal of Clinical Biochemistry and Nutrition·Biju C Mathew, Reji Susan Daniel
Jun 18, 2010·Biology of Reproduction·Jessica D SherrillBenson T Akingbemi
Apr 23, 2013·European Journal of Nutrition·Hongwei SiDongmin Liu
Dec 24, 2018·Biology of Sex Differences·Jane F Reckelhoff, Barbara T Alexander
Jul 1, 2015·Journal of Microscopy and Ultrastructure·Eman Ali El-Kordy, Abdulrahman Mohammed Alshahrani
Apr 3, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kayo HorieHayato Maeda
Jul 26, 2019·Medicine and Science in Sports and Exercise·Afton D SeeleyJoseph F Signorile
Apr 17, 2020·Frontiers in Endocrinology·Jing Luo, Dongmin Liu
Apr 19, 2012·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Zhuo FuDongmin Liu
Mar 25, 2011·Critical Reviews in Food Science and Nutrition·R GonzálezF Sánchez de Medina
Oct 6, 2009·Journal of Food Science·M Viuda-MartosJ A Pérez-Alvarez
Jul 4, 2012·Molecular Nutrition & Food Research·Pon V Anandh BabuDongmin Liu
Nov 10, 2020·European Journal of Clinical Nutrition·Lili BarskyC Noel Bairey Merz
Nov 11, 2020·Applied Microbiology and Biotechnology·Heesu Kim, Dong Gun Lee
May 3, 2019·The Journal of Nutritional Biochemistry·Lijuan ZhangHongwei Si
May 23, 2020·Gene·Firouzeh GholampourSeyed Mohammad Owji
Aug 20, 2008·Journal of Agricultural and Food Chemistry·Siyuan ZhouQibing Mei
Jun 3, 2021·International Journal of Molecular Sciences·Jurga BernatonieneDalia Marija Kopustinskiene

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