Genistein has beneficial effects on hepatic steatosis in high fat-high sucrose diet-treated rats

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Huanhuan LiuZhuoqin Jiang

Abstract

Genistein, a kind of phytoestrogen abundant in soybeans, is beneficial for alleviating non-alcoholic fatty liver disease (NAFLD), but the specific mechanism was not clearly understood. This study was designed to determine the effect of genistein on NAFLD and explore the possible mechanism. 36 male Sprague-Dawley rats were divided into 4 groups: the control group, high fat-high sucrose diet (HFS) group, HFS with 4mg/kg body weight genistein, and HFS with 8mg/kg body weight genistein. 12 weeks later, serum and hepatic lipid profiles, liver histopathological examination were characterized. The protein levels of liver AMP-activated protein kinase (AMPK), phosphorylation of AMPK (p-AMPK), acetyl-CoA carboxylase (ACC), phosphorylation of ACC (p-ACC) and sterol regulatory element binding protein 1 (SREBP-1) were determined by western blot. mRNA expressions of fatty acid synthase gene (FAS) and glycerol-3-phosphate acyltransferase (GPAT), peroxisome proliferator-activated receptor α (PPARα), carnitine palmitoyl transfer enzyme-1 (CPT-1) and acyl-CoA oxidase (ACO) were measured by reverse transcription polymerase chain reaction (RT-PCR). Results showed that genistein effectively improved serum and hepatic lipid metabolism and diminished...Continue Reading

Citations

Sep 29, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ming HongYibin Feng
Jul 18, 2019·Journal of Food Science·Rongrong LuZhuoqin Jiang
Mar 4, 2020·International Journal of Molecular Sciences·Madhulika TripathiBrijesh Kumar Singh
Mar 20, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Taewon YukJunsoo Lee
Jul 8, 2020·International Journal of Molecular Sciences·Da Eun KimSung Yeon Kim
Sep 25, 2019·International Journal of Molecular Sciences·Luis E Soria-JassoEduardo Fernández-Martínez
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yimin YinZhuoqin Jiang
Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lena SeidemannGeorg Damm
Apr 27, 2021·International Journal of Food Sciences and Nutrition·Xuemei WangRennan Feng
May 18, 2021·The Journal of Nutritional Biochemistry·Sarai Vásquez-ReyesArmando R Tovar

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