Genistein improves sensorimotor gating: Mechanisms related to its neuroprotective effects on the striatum

Neuropharmacology
Esther T MenzeAshraf B Abdel-Naim

Abstract

Huntington's disease (HD) is a neurodegenerative disorder, characterized by selective atrophy in the striatum, particularly the medium spiny GABAergic efferent neurons. This results in striatal sensorimotor gating deficits. Systemic administration of 3-nitropropionic acid (3-NPA) produces selective lesions mimicking those of HD. Males were found to be more susceptible to 3-NPA-induced neurotoxicity than females, suggesting neuroprotective effects of estrogens. Phytoestrogens, including genistein, are good estrogenic alternatives that keep their beneficial effects on non-reproductive organs and lack the potential hazardous side effects. The current study was designed to investigate the potential beneficial effects of genistein in 3-NPA-induced HD in ovariectomized rats. Results showed that 3-NPA (20 mg/kg) administration caused significant disruption of the rats' locomotor activity and prepulse inhibition. In addition, it decreased striatal ATP levels and increased oxidative stress, inflammatory and apoptotic markers with striatal focal hemorrhage and gliosis. Pretreatment with 17β-estradiol (2.5 mg/kg) or genistein (20 mg/kg) led to a significant improvement of behavioral parameters, increased ATP production, decreased oxidativ...Continue Reading

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Citations

Oct 25, 2017·Nutritional Neuroscience·Derek A Schreihofer, Anthony Oppong-Gyebi
Feb 13, 2018·Neuromolecular Medicine·Karolina PierzynowskaGrzegorz Węgrzyn
Jun 27, 2019·International Journal of Molecular Sciences·Pamela Maher
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ioannis BakoyiannisDespina Perrea

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