Genistein induces macrophage polarization and systemic cytokine to ameliorate experimental colitis

PloS One
Jessicca D AbronUdai P Singh

Abstract

Mucosal changes in Crohn's disease (CD) and ulcerative colitis (UC), two major forms of inflammatory bowel disease (IBD), are characterized by a prominent infiltration of inflammatory cells including lymphocytes, macrophages, T cells and neutrophils. The precise etiology of IBD is unknown but it involves a complex interplay of factors associated with the immune system, environment, host genotype and enteric commensal bacteria. As there is no known safe cure for IBD, natural alternative therapeutic options without side effects are urgently needed. To this end, Soy-based foods, which have been eaten for centuries in Asian countries, have potential benefits, including lowering the incidence of coronary heart disease, atherosclerosis, type-2 diabetes, allergic response, and autoimmune diseases. This study describes the effect of Soy isoflavons 4', 5, 7 Trihydroxyisoflavone (genistein) on dextran sodium sulphate (DSS) induced experimental colitis. The extent and severity of disease was analyzed through body weight, histopathological analysis, cellular immune response, systemic cytokine levels, and inflammation score using a disease activity index. Genistein treatment significantly attenuated DSS-induced colitis severity and resulted...Continue Reading

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Citations

Jan 5, 2019·The Journal of Pharmacology and Experimental Therapeutics·Si-Wei WangFeng Zhang
Oct 19, 2019·Microbiology and Immunology·Se-Eun Jang, Sung-Won Min
Feb 29, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mukesh KumarBilly Kwok Chong Chow
Apr 3, 2020·Archivum Immunologiae Et Therapiae Experimentalis·Seyede Sara SeyedizadeAmir Hossein Abdolghaffari
May 18, 2020·Current Nutrition Reports·Layla Al-Nakkash, Aaron Kubinski
Jun 18, 2020·World Journal of Clinical Cases·Ze-Yu WuBing Chang
Oct 25, 2020·Biological Trace Element Research·Mostafa Vaghari-TabariAmir Ghorbanihaghjo
Mar 9, 2021·Expert Opinion on Therapeutic Targets·Yaoyao DuBing Wang
Jan 19, 2020·Current Opinion in Biotechnology·Ruisong PeiBradley Bolling
Mar 24, 2021·International Journal of Cancer. Journal International Du Cancer·Rajitha IndukuriCecilia Williams
May 1, 2021·Foods·Abigail Raffner BassonFabio Cominelli
Apr 30, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Qi LvYinan Zhang
Jun 3, 2021·Current Issues in Molecular Biology·Matúš ČomaPeter Gál
Aug 3, 2021·Frontiers in Pharmacology·Linshan DuanGuoyan Liu
Aug 24, 2021·ACS Applied Materials & Interfaces·Wentao FanSuquan Song
Nov 27, 2021·Phytotherapy Research : PTR·Fahimeh Zamani-GarmsiriReza Meshkani

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Methods Mentioned

BETA
FACS
flow cytometry
ELISA

Software Mentioned

BioRad
XLStat
Statview

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