Genistein: is the multifarious botanical a natural anthelmintic too?

Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology
V Tandon, B Das

Abstract

Genistein (4',5,7-trihydroxyisoflavone) is naturally present in plants of the soy family and is known to have various pharmacological activities, such as anti-cancer, anti-diabetic, anti-oxidant, etc. The phytoestrogen is one of the major isoflavones found in some medicinal plants having anthelmintic properties. This review describes the putative role of genistein as an anthelmintic, which has been tested on some helminth parasites in vitro. Genistein has been shown to cause paralysis and alterations in the tegument and tegumental enzymes (acid phosphatase, alkaline phosphatase, adenosine triphosphatase, and 5'-nucleotidase) of helminth parasites. Alterations in the activities of several enzymes associated with the coordination system (specifically non-specific esterases, acetylcholine esterase, and nitric oxide synthase), and changes in the concentration of nitric oxide, cGMP, free amino acid pool, and tissue ammonia are observed in helminth parasites treated with genistein. The phytoestrogen also affects the carbohydrate metabolism by altering the activities of key enzymes involved in glycogen- and glucose-metabolism of a cestode parasite. Considering the significance of phosphoenolpyruvate carboxykinase (PEPCK) in glycolysis...Continue Reading

References

Mar 1, 1991·Journal of Ethnopharmacology·M Del Rayo CamachoR Mata
Jan 1, 1988·Transactions of the Royal Society of Tropical Medicine and Hygiene·J M DidierH I McKenzie
Jan 1, 1995·Proceedings of the Society for Experimental Biology and Medicine·S Barnes, T G Peterson
Jan 1, 1995·Proceedings of the Society for Experimental Biology and Medicine·C A LamartiniereS Barnes
Jun 1, 1996·Journal of Helminthology·N K GhoshA Ito
Aug 15, 1998·Archives of Biochemistry and Biophysics·A AroraG M Strasburg
Nov 25, 1998·Archives of Biochemistry and Biophysics·J H MitchellG G Duthie
Jul 15, 1999·International Journal for Parasitology·N B TereninaM K Gustafsson
Mar 11, 2000·American Journal of Physiology. Endocrinology and Metabolism·C LavigneH Jacques
Oct 12, 2000·Journal of Ethnopharmacology·S G SpargA K Jäger
Mar 29, 2001·Journal of Ethnopharmacology·P MølgaardJ Andreassen
Apr 20, 2001·Journal of Agricultural and Food Chemistry·F SheuG C Yen
Apr 24, 2001·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·N M EnweremP A Akah
Oct 12, 2001·Parasitology International·V TandonN Saha
Jun 11, 2002·The Journal of Parasitology·J R A LyddiardA Bartlett
Jun 27, 2002·British Journal of Cancer·C NagataH Shimizu
Jan 1, 1996·Parasitology Today·C A RedmanR J Martin
Oct 1, 1992·Parasitology Today·T A DayR A Pax
Oct 29, 2004·Phytochemical Analysis : PCA·Oldrich LapcíkJitka Moravcová
Jan 3, 2006·Journal of Ethnopharmacology·Vareishang TangpuArun K Yadav
Feb 24, 2006·Archives of Pharmacal Research·Hyekyung HaChungsook Kim

❮ Previous
Next ❯

Citations

Jul 17, 2020·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Madison RemickTaylor J Abel
Mar 6, 2021·Helminthologia·D FaixováD Mudroňová

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.