Genistein reverses isoproterenol-induced cardiac hypertrophy by regulating miR-451/TIMP2

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Mailin GanLi Zhu

Abstract

Cardiomyocyte hypertrophy, a prevalent clinical condition is deeply associated with many physiological factors. The underlying mechanisms of cardiomyocyte hypertrophy are not yet fully understood. In this study, H9C2 cells were treated with genistein, miR-451 mimic, miR-451 inhibitor and isoproterenol for 24 h, to study the effect of genistein on isoproterenol-induced myocardial hypertrophy in vitro. Simultaneously, ICR mice were treated with genistein for 21 days to evaluate the effects of the phytochemical on isoproterenol-induced myocardial hypertrophy in vivo. Results showed that isoproterenol induced cardiac hypertrophy and down-regulated the expression of miR-451 and up-regulated miR-451's target gene TIMP2. Genistein increased the expression of miR-451 and inhibited the isoproterenol-induced cardiac hypertrophy. This study explored the function of genistein from the epigenetic level, suggesting that miR-451 may play a significant role in the genistein-assisted amelioration of isoproterenol-induced cardiac hypertrophy both in vitro and in vivo.

References

Feb 21, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Chunhua CaoSuhn Hee Kim
Sep 21, 2004·Annual Review of Plant Biology·Richard A Dixon
May 1, 2007·Nature Medicine·Alessandra CarèGianluigi Condorelli
May 26, 2007·The American Journal of Pathology·Yunhui ChengChunxiang Zhang
Apr 2, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Shigenori NobataYoshio Takei
Aug 20, 2010·Reproductive Sciences·Warren B Nothnick, Caitlin Healy
Apr 16, 2011·International Journal of Biological Sciences·Xueying TanYanjie Lu
Jul 20, 2012·Canadian Journal of Physiology and Pharmacology·Subir Kumar MaulikSandeep Seth
Mar 16, 2013·Physiological Research·H TurkováT Zelinka
Jun 25, 2014·Cardiovascular Research·Dirk Westermann, Stephane Heymans
Sep 12, 2014·Journal of Cellular and Molecular Medicine·Lei SongJizheng Wang
Jul 15, 2015·Cell Death and Differentiation·Z LiX Yang
Mar 16, 2016·Cardiovascular Research·Zhenhua LiJian Wang
Apr 9, 2016·Journal of Molecular and Cellular Cardiology·Dimitry A ChistiakovYuri V Bobryshev
Mar 23, 2017·Experimental Cell Research·Yi LiuWei-Ming Fu
Oct 27, 2017·Critical Reviews in Oncology/hematology·Vidya MukundAfroz Alam
Apr 19, 2018·Journal of Pharmacy Practice·Julie D'Ambrosi, Nilesh Amin
Jun 6, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Linyuan ShenLi Zhu
Jul 1, 2018·Experimental Gerontology·Richard A PerryTyrone A Washington
Jul 6, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lenka FáberPeter Gál

❮ Previous
Next ❯

Citations

May 30, 2019·Journal of Cellular Physiology·Monireh KhordadmehrBehzad Baradaran
Dec 11, 2019·International Journal of Molecular Sciences·Mailin GanLi Zhu
Oct 22, 2020·Animals : an Open Access Journal From MDPI·Mailin GanLi Zhu
Oct 22, 2020·Critical Reviews in Food Science and Nutrition·Ankita KumariRajeev Kapila
Sep 27, 2019·Food Research International·Lívia Beatriz Aparecida Ribeiro SilvaThomas Prates Ong
Jun 11, 2021·Molecular Medicine Reports·Chunrong WuDebing Xiang
Jul 30, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Beilei ZhangFu Wang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.