Genistein stimulates insulin sensitivity through gut microbiota reshaping and skeletal muscle AMPK activation in obese subjects

BMJ Open Diabetes Research & Care
Martha Guevara-CruzArmando R Tovar

Abstract

Obesity is associated with metabolic abnormalities, including insulin resistance and dyslipidemias. Previous studies demonstrated that genistein intake modifies the gut microbiota in mice by selectively increasing Akkermansia muciniphila, leading to reduction of metabolic endotoxemia and insulin sensitivity. However, it is not known whether the consumption of genistein in humans with obesity could modify the gut microbiota reducing the metabolic endotoxemia and insulin sensitivity. 45 participants with a Homeostatic Model Assessment (HOMA) index greater than 2.5 and body mass indices of ≥30 and≤40 kg/m2 were studied. Patients were randomly distributed to consume (1) placebo treatment or (2) genistein capsules (50 mg/day) for 2 months. Blood samples were taken to evaluate glucose concentration, lipid profile and serum insulin. Insulin resistance was determined by means of the HOMA for insulin resistance (HOMA-IR) index and by an oral glucose tolerance test. After 2 months, the same variables were assessed including a serum metabolomic analysis, gut microbiota, and a skeletal muscle biopsy was obtained to study the gene expression of fatty acid oxidation. In the present study, we show that the consumption of genistein for 2 month...Continue Reading

Citations

Jul 31, 2020·Molecular Nutrition & Food Research·Monica Sánchez-TapiaArmando R Tovar
Jan 1, 2021·International Journal of Molecular Sciences·Alina Kuryłowicz
Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Feijie ZhaoSongling Zhang
Mar 19, 2021·Phytotherapy Research : PTR·Syed Afroz AliAshok Kumar Datusalia
Apr 30, 2021·Biochemical and Biophysical Research Communications·Xi ChenXingxing Zhang
May 18, 2021·The Journal of Nutritional Biochemistry·Sarai Vásquez-ReyesArmando R Tovar
Jul 3, 2021·International Journal of Molecular Sciences·Shiyao ZhangSiyu Chen

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
ELISA
biopsies
PCR

Software Mentioned

GraphPad Prism
LEfSe
Statistical Package for the Social Sciences ( SPSS )
Partek Genomics Suite
Emperor
ImageJ
Partek
Expression Console
Phylogenetic Investigation of Communities by Reconstruction of...
PICRUSt

Related Concepts

Related Feeds

American Diabetes Association Journals

Discover the latest diabetes research published by the journals from the American Diabetes Association.