May 1, 1993

Genital cancer and Langerhans cells

In Vivo
L Aurelian


This review describes the role of Langerhans cells (LC) in immunity and suggests that they participate in immunosurveillance. Evidence is presented for the role of the LA-1 oncogene in cervical carcinogenesis. A hypothesis is presented in which LC are involved: (i) in presentation of the LA-1 oncoprotein to the immune system thereby inducing killer T cell responses against neoplastic epithelial cells, and (ii) direct interaction with LA-1 oncoprotein positive tumor cells including expression of adhesion molecules that may affect morphology/interaction of normal cervical cells. Predictions made by this hypothesis, which can be tested experimentally, are listed.

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Mentioned in this Paper

Tumor Cells, Uncertain Whether Benign or Malignant
Immune System
Squamous Transitional Epithelial Cell Count
Science of Morphology
Hepatitis A
Cytotoxic T-Lymphocytes
Dermal Dendritic Cells
Oncogene Proteins

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