PMID: 9170460Jun 1, 1997Paper

Genital herpes during pregnancy: inability to distinguish primary and recurrent infections clinically

Obstetrics and Gynecology
P A HensleighC G Prober

Abstract

To determine if the signs and symptoms of genital herpes in pregnancy accurately identify primary genital herpes infections using serologic testing for final classification. Twenty-three women with clinical signs and symptoms suggestive of primary genital herpes infections in the second and third trimesters of pregnancy were subsequently cultured and tested serologically (for herpes simplex virus type 1 and herpes simplex virus type 2 antibodies) and classified as having true primary (no herpes simplex virus type 1 or type 2 antibodies), nonprimary (heterologous herpes simplex virus antibodies present), or recurrent (homologous antibodies present) infections. Only one of 23 women with clinical illnesses consistent with primary genital herpes virus simplex infections had serologically-verified primary infection. This primary infection was caused by herpes simplex virus type 1. Three women had nonprimary type 2 infections, and 19 women had recurrent infections. Among culture-proven recurrent infections, 12 were caused by herpes simplex virus type 2 and three by herpes simplex virus type 1. Only one infant was born preterm, and no clinically significant perinatal morbidity was observed. Correct classification of gestational genita...Continue Reading

References

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Citations

May 18, 2000·Reviews in Medical Virology·D WilkinsonF Cowan
Sep 15, 2000·Infectious Disease Clinics of North America·J D Fingeroth
Dec 4, 2003·Journal of Clinical Anesthesia·Krzysztof M Kuczkowski, Laurence S Reisner
Oct 3, 2009·The New England Journal of Medicine·Lawrence Corey, Anna Wald
Apr 19, 2012·Clinical Obstetrics and Gynecology·Oluwatosin JaiyeobaJ Michael Kilby
Dec 3, 2014·Obstetrics and Gynecology Clinics of North America·Alyssa Stephenson-Famy, Carolyn Gardella
Jun 1, 2005·BJOG : an International Journal of Obstetrics and Gynaecology·Kirsten Lawrence ClearyGeorge A Macones
Jan 19, 1999·Dermatologic Clinics·Z A Brown
Oct 3, 2003·Expert Opinion on Pharmacotherapy·Daniel T Leung, Stephen L Sacks
Feb 15, 2002·Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN·Deborah Blair Donahue
Oct 4, 2005·Obstetrics and Gynecology·Zane A BrownLawrence Corey
Aug 17, 1999·Sexually Transmitted Infections·Q Abdool Karim, S S Abdool Karim
Jul 8, 1999·Obstetrical & Gynecological Survey·A H Kang, C R Graves
May 18, 2000·Reviews in Medical Virology·Z A Brown
Sep 17, 1998·Seminars in Perinatology·L E Riley

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