PMID: 8940669Oct 1, 1996Paper

Genital ulcer disease among STD clinic attenders in Nairobi: association with HIV-1 and circumcision status

International Journal of STD & AIDS
J M NasioF A Plummer

Abstract

In previous studies, genital ulcers in men have been found to be associated with increased risk of HIV-1 seroconversion. To further explore this association male patients attending a sexually transmitted disease (STD) clinic in Nairobi for either urethritis (controls, n = 276) or a genital ulcer (cases, n = 607) were compared with respect to sexual behaviour, presence of HIV-1 antibody and circumcision status. Patients were followed to study risk factors for incident genital ulcers and HIV-1 seroconversion. At entry, being married was associated with higher prevalence of HIV-1 (OR = 1.76) and genital ulcers (OR = 1.42). Lack of circumcision was associated with both HIV-1 infection (OR = 4.67) and the presence of a genital ulcer (OR = 2.23). Genital ulcers were also associated with HIV-1 infection (OR = 1.87) independent of circumcision status. On follow-up, HIV-1 seropositivity was associated with incident genital ulcers. It is argued that the association between genital ulcers and HIV-1 infection may be more complex than ulcers simply being a risk factor for HIV-1 infection, and that HIV-1 infection may either increase the risk of acquiring a genital ulcer, or HIV-1 infection and genital ulcers may have some unknown risk facto...Continue Reading

Citations

Mar 16, 2005·The Lancet Infectious Diseases·N SiegfriedP Williamson
Nov 28, 2013·The Journal of Infectious Diseases·Jessica L ProdgerUNKNOWN Rakai Genital Immunology Research Group
Apr 9, 1999·Sexually Transmitted Infections·P M FleissR S Van Howe
Apr 9, 1999·Sexually Transmitted Infections·S MosesA R Ronald
Feb 28, 2001·Sexually Transmitted Infections·R A DisekerM Iatesta
May 7, 2004·Epidemiology·Kawango E AgotNoel S Weiss
Apr 21, 2004·Obstetrical & Gynecological Survey·Mark C Alanis, Richard S Lucidi
May 28, 2005·Expert Review of Anti-infective Therapy·Naa Torshie Annan, David A Lewis
Sep 3, 2008·The Journal of Sexual Medicine·John N KriegerStephen Moses
Jan 5, 2002·Reproductive Health Matters·K Bonner
Dec 16, 2005·The Journal of the Royal Society for the Promotion of Health·Robert S Van HoweFrederick M Hodges
Oct 26, 2001·Sexually Transmitted Diseases·E L KorenrompJ D Habbema
Jun 14, 2001·Sexually Transmitted Diseases·R A DisekerM Iatesta
Feb 23, 2017·World Journal of Clinical Pediatrics·Brian J MorrisJohn B Ziegler
Feb 28, 2007·Sexually Transmitted Diseases·Yuhua RuanYiming Shao
Apr 24, 1999·International Journal of STD & AIDS·R S Van Howe
Sep 10, 2019·Journal of Evidence-based Medicine·Brian J MorrisJohn N Krieger
Jun 22, 2010·Sexually Transmitted Diseases·Sue Napierala MavedzengeAriane van der Straten

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