Genitogluteal porokeratosis: a clinical review

Clinical, Cosmetic and Investigational Dermatology
Rajiv Joshi, Khushboo Minni

Abstract

Porokeratosis is an uncommon disorder of keratinization that presents with keratotic papules or annular plaques that expand centrifugally with a thread-like elevated border. A distinctive histologic structure, the cornoid lamella, is diagnostic of this disorder and consists of a column of parakeratosis with the absence of the granular layer and dyskeratotic cells in the upper spinous zone. Porokeratosis confined to the genitogluteal region is rare and may be subclassified into three types, namely, classical porokeratosis on the genital region, ptychotropic porokeratosis most often seen in the natal cleft and buttocks and penoscrotal porokeratosis that is seen on the penis and adjacent scrotal skin in young men in their third decade of life. Genitogluteal porokeratosis is usually pruritic and may be undiagnosed for several years as it does not resemble classical porokeratosis in many cases; however, a biopsy is diagnostic. In general, response of genital porokeratosis to any modality of treatment is disappointing. No malignant changes have hereto been reported in porokeratosis restricted to the genitogluteal region.

Citations

Oct 31, 2018·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·Susanne Darr-Foit, Peter Elsner
Apr 20, 2021·Indian Journal of Dermatology, Venereology and Leprology·Deniz Demircioğlu DumanSedef Şahin
Jul 11, 2021·Indian Journal of Dermatology, Venereology and Leprology·Kun Qin, Lei Yu
Aug 22, 2021·Pediatric Dermatology·Bianca Y KangIsrael D Andrews

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Methods Mentioned

BETA
biopsy

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