Genitourinary cancer patients have worse baseline semen parameters than healthy sperm bankers

Andrology
R XuC Tanrikut

Abstract

While the spermatotoxic properties of cancer treatments such as chemotherapy and radiation therapy are widely recognized, the effect of malignancy itself on male fertility is not clearly understood. To determine whether malignancy is associated with diminished semen quality prior to spermatotoxic treatment among sperm bankers. Retrospective database review of de-identified records was obtained for all episodes of sperm banking performed at a cryobank from January 2004 to May 2017 for one of the following reasons: 'future use' (e.g., military deployment and gender reassignment); infertility; benign disease; and malignancy, further categorized as testicular, other genitourinary (GU), solid non-GU, hematologic, or unspecified. Dependent variables of interest were ejaculatory volume, sperm concentration, % motility, and total motile sperm count (TMSC), as well as post-thaw TMSC. A total of 1558 patients met the inclusion criteria. Multivariable regression analysis on log-transformed data controlling for age demonstrated decreased ejaculatory volume and sperm concentration, % motility, and TMSC in the infertility group as compared to the 'future use' group (p < 0.001). Testicular cancer was associated with decreased sperm concentrat...Continue Reading

References

Mar 26, 2004·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Karine ChungPasquale Patrizio
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Dec 21, 2017·Reproductive Medicine and Biology·Itsuto HamanoChikara Ohyama

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