Genome analysis and phylogenetic relationships between east, central and west African isolates of Yellow fever virus

The Journal of General Virology
Jana J von LindernA D Barrett

Abstract

Yellow fever virus (YFV), a reemerging disease agent in Africa and South America, is the prototype member of the genus Flavivirus. Based on examination of the prM/M, E and 3' non-coding regions of the YFV genome, previous studies have identified seven genotypes of YFV, including the Angolan, east/central African and east African genotypes, which are highly divergent from the prototype strain Asibi. In this study, full genome analysis was used to expand upon these genetic relationships as well as on the very limited full genome database for YFV. This study was the first to investigate genomic sequences of YFV strains from east and central Africa (Angola71, Uganda48a and Ethiopia61b). All three viruses had genomes of 10 823 nt in length. Compared with the prototype strain Asibi (from west Africa) they were approximately 25 % divergent in nucleotide sequence and 7 % divergent in amino acid sequence. Comparison of multiple flaviviruses in the N-terminal region of NS4B showed that amino acid sequences were variable and that west African strains of YFV had an amino acid deletion at residue 21. Additionally, N-linked glycosylation sites were conserved between viral genotypes, while codon usage varied between strains.

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Citations

Jun 7, 2012·Nucleic Acids Research·Shiliang WangTimothy B Stockwell
Jul 16, 2010·Journal of Virology·Albert J AugusteChristine V F Carrington
Aug 18, 2006·Annual Review of Entomology·Alan D T Barrett, Stephen Higgs
Feb 26, 2015·The Journal of General Virology·Justin A RobyAlexander A Khromykh
Dec 3, 2010·The Journal of General Virology·Amy J SchuhAlan D T Barrett
Sep 18, 2012·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Christine V F Carrington, Albert J Auguste
Oct 4, 2011·Virology·Laura K McMullanStuart T Nichol
Jun 10, 2016·Virology Journal·Formijn van Hemert, Ben Berkhout
Jul 14, 2016·Emerging Microbes & Infections·Zhihai ChenDexin Li
Aug 31, 2018·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Jean-Philippe Chippaux, Alain Chippaux
Dec 20, 2019·Journal of Biomolecular Structure & Dynamics·Stephane Fraga de Oliveira TostaLuiz Carlos Junior Alcantara
Jul 28, 2019·BioMed Research International·Huipeng YaoZizhong Tang

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