Genome Analysis of the Fruiting Body-Forming Myxobacterium Chondromyces crocatus Reveals High Potential for Natural Product Biosynthesis

Applied and Environmental Microbiology
Nestor ZaburannyiRolf Müller

Abstract

Here, we report the complete genome sequence of the type strain of the myxobacterial genus Chondromyces, Chondromyces crocatus Cm c5. It presents one of the largest prokaryotic genomes featuring a single circular chromosome and no plasmids. Analysis revealed an enlarged set of tRNA genes, along with reduced pressure on preferred codon usage compared to that of other bacterial genomes. The large coding capacity and the plethora of encoded secondary metabolite biosynthetic gene clusters are in line with the capability of Cm c5 to produce an arsenal of antibacterial, antifungal, and cytotoxic compounds. Known pathways of the ajudazol, chondramide, chondrochloren, crocacin, crocapeptin, and thuggacin compound families are complemented by many more natural compound biosynthetic gene clusters in the chromosome. Whole-genome comparison of the fruiting-body-forming type strain (Cm c5, DSM 14714) to an accustomed laboratory strain which has lost this ability (nonfruiting phenotype, Cm c5 fr-) revealed genetic changes in three loci. In addition to the low synteny found with the closest sequenced representative of the same family, Sorangium cellulosum, extensive genetic information duplication and broad application of eukaryotic-type sign...Continue Reading

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Citations

Oct 28, 2017·Genome Announcements·Anke Treuner-LangeLotte Søgaard-Andersen
Oct 28, 2017·Genome Announcements·Anke Treuner-LangeLotte Søgaard-Andersen
Nov 11, 2017·Genome Announcements·Anke Treuner-LangeLotte Søgaard-Andersen
Aug 16, 2017·Angewandte Chemie·Filip BihelovicDirk Trauner
Nov 8, 2017·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Muhammad Yasir
Jul 22, 2017·Annual Review of Microbiology·Jörg OvermannJohannes Sikorski
Aug 4, 2018·Frontiers in Microbiology·Gaurav SharmaMitchell Singer

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