Genome and proteome analysis of Chlamydia

Proteomics
Brian B S VandahlGunna Christiansen

Abstract

It has been difficult to study the molecular biology of the obligate intracellular bacterium Chlamydia due to lack of genetic transformation systems. Therefore, genome sequencing has greatly expanded the information concerning the biology of these pathogens. Comparing the genomes of seven sequenced Chlamydia genomes has provided information of the common gene content and gene variation. In addition, the genome sequences have enabled global investigation of both transcript and protein content during the developmental cycle of chlamydiae. During this cycle Chlamydia alternates between an infectious extracellular form and an intracellular dividing form surrounded by a phagosome membrane termed the chlamydial inclusion. Proteins secreted from the chlamydial inclusion into the host cell may interact with host cell proteins and modify the host cell's response to infection. However, identification of such proteins has been difficult because the host cell cytoplasm of Chlamydia infected cells cannot be purified. This problem has been circumvented by comparative proteomics.

Citations

Oct 28, 2005·Antimicrobial Agents and Chemotherapy·Rachel Binet, Anthony T Maurelli
Oct 26, 2010·Journal of Bacteriology·Silvia KnabIlka Haferkamp
Feb 14, 2006·Annals of the Rheumatic Diseases·M RihlH Zeidler
May 6, 2014·Expert Opinion on Drug Discovery·Leena Hanski, Pia M Vuorela
Apr 9, 2009·Journal of Medical Entomology·J G ScottA G Clark
Feb 21, 2008·Current Opinion in Chemical Biology·Hsing-Ju WuMichael P Jennings
Oct 20, 2006·Trends in Microbiology·Radhey S Gupta, Emma Griffiths
Mar 3, 2009·Proteomics·Malgorzata KowalczewskaDidier Raoult
Jun 9, 2006·Vaccine·Peter J Hotez, Meghan T Ferris
Oct 3, 2015·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Tomohiro YamazakiHiroyuki Yamaguchi
Nov 30, 2006·Journal of Biochemistry and Molecular Biology·Song-Mee BaeKwang-Jun Lee
Jan 1, 2012·Genes·Fotis E PsomopoulosChristos A Ouzounis
Jan 22, 2019·Critical Reviews in Microbiology·Signe ChristensenWilhelmina M Huston
Feb 26, 2020·Critical Reviews in Microbiology·Arlieke GitselsDaisy Vanrompay
Jan 22, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hong YuRobert C Brunham
Oct 28, 2019·Frontiers in Microbiology·Arlieke GitselsDaisy Vanrompay

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.