Genome-based epidemiology and antimicrobial resistance determinants of Neisseria gonorrhoeae isolates with decreased susceptibility and resistance to extended-spectrum cephalosporins in Argentina in 2011-16

The Journal of Antimicrobial Chemotherapy
Ricardo GianeciniGonococcal Antimicrobial Susceptibility Surveillance Programme-Argentina (GASSP-AR) Working Group

Abstract

Our aim was to describe the molecular epidemiology and antimicrobial resistance determinants of isolates of Neisseria gonorrhoeae with decreased susceptibility and resistance to extended-spectrum cephalosporins (ESCs) in Argentina in 2011-16. Gonococcal isolates (n=158) with decreased susceptibility and resistance to ESCs collected in 2011-16 across Argentina were subjected to WGS and antimicrobial susceptibility testing for six antimicrobials. In total, 50% of the isolates were resistant to cefixime, 1.9% were resistant to ceftriaxone, 37.3% were resistant to azithromycin and 63.9% of the isolates showed an MDR phenotype. Resistance and decreased susceptibility to ESCs was mainly associated with isolates possessing the mosaic penA-34.001, in combination with an mtrR promoter A deletion, and PorB1b amino acid substitutions G120K/A121N. Phylogenetic analysis revealed two main clades of circulating strains, which were associated with the N. gonorrhoeae multiantigen sequence typing (NG-MAST) ST1407 and closely related STs, and characterized by a high prevalence rate, wide geographical distribution and temporal persistence. N. gonorrhoeae isolates with decreased susceptibility and resistance to ESCs in Argentina have emerged and ra...Continue Reading

References

Dec 21, 2002·The Journal of Antimicrobial Chemotherapy·Sydney L CousinMarilyn C Roberts
Jun 10, 2009·Bioinformatics·Heng LiUNKNOWN 1000 Genome Project Data Processing Subgroup
Sep 9, 2009·Expert Review of Anti-infective Therapy·John W TapsallMagnus Unemo
Oct 5, 2010·Enfermedades infecciosas y microbiología clínica·José M Peña
Nov 26, 2010·Antimicrobial Agents and Chemotherapy·Vanessa G AllenRoberto G Melano
Sep 5, 2013·Journal of Midwifery & Women's Health
Jan 9, 2014·International Journal of STD & AIDS·C BignellUNKNOWN European STI Guidelines Editorial Board
Jul 2, 2014·Clinical Microbiology Reviews·Magnus Unemo, William M Shafer
Apr 14, 2016·Antimicrobial Agents and Chemotherapy·Shu-Ichi NakayamaMakoto Ohnishi
May 19, 2016·Emerging Infectious Diseases·Ricardo GianeciniPatricia Galarza
Jun 23, 2016·The New England Journal of Medicine·Helen FiferMagnus Unemo
Oct 30, 2016·The Lancet Infectious Diseases·Dilrini De SilvaDavid W Eyre
May 13, 2017·Sexually Transmitted Diseases·Ricardo GianeciniUNKNOWN Gonococcal Antimicrobial Susceptibility Surveillance Programme-Argentina (GASSP-AR) Working Group
Jul 14, 2017·The Lancet Infectious Diseases·Magnus UnemoChristopher K Fairley
Oct 27, 2017·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·David TerkelsenHenrik Westh
Nov 14, 2017·Emerging Infectious Diseases·Brigitte LefebvreJean Longtin
May 20, 2018·The Lancet Infectious Diseases·Simon R HarrisUNKNOWN Euro-GASP study group
May 31, 2018·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Thibault PoncinBeatrice Bercot
Jul 12, 2018·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·David W EyreMonique I Andersson
Nov 30, 2018·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Daniel GolparianMagnus Unemo

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Citations

Dec 6, 2019·Medical Microbiology and Immunology·Beata Młynarczyk-BonikowskaSławomir Majewski
May 23, 2020·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Iryna BoikoMagnus Unemo
Aug 14, 2020·The Journal of Antimicrobial Chemotherapy·Daniel GolparianUNKNOWN Brazilian-GASP Network
Feb 19, 2020·The Journal of Antimicrobial Chemotherapy·Pham Thi LanMagnus Unemo
Jun 26, 2021·Briefings in Functional Genomics·Reema SinghJo-Anne R Dillon
Aug 8, 2021·Annals of Clinical Microbiology and Antimicrobials·Konrad EgliThomas Bodmer
Aug 24, 2021·Emerging Infectious Diseases·Ricardo Ariel GianeciniUNKNOWN Gonococcal Antimicrobial Susceptibility Surveillance Programme—Argentina1
Dec 8, 2021·Expert Review of Molecular Diagnostics·Daniel Golparian, Magnus Unemo

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