Genome dimensions control biological and toxicological functions; myth or reality?

Cell Biology and Toxicology
Diane C Wang, Xiangdong Wang

Abstract

The multidimensional genome offers a new perspective to understand molecular mechanisms of genotoxicity and provide deeper knowledge of how genome organization and reorganization in dimensions can alter cell sensitivity, tolerance, resistance, or toxicity to drugs, whether drugs per se can influence the 3D architecture of the genome directly or indirectly through transcriptional factors, and how we can improve cell sensitivity to drugs through the reorganization of genome and regulation of gene expression. We address roles of 3D genome organization and reorganization in the pathogenesis and progression of disease by evaluating various methodologies of studying the 3D genome, and in the genome integrity and stability susceptible to chemicals as mechanisms of genotoxicity. We discuss the value of imaging, visualizing, and nuclear proximity ligation-based methods of 3D genome organization to measure spatial proximity and visualize spatial distances between genomic loci. We also list a number of dynamic genome changes during genome function and call for further investigations on the interaction of drugs with genome-specific regulators, key enzymes, or spliceosome.

References

Apr 1, 1993·Trends in Genetics : TIG·A McLaren
Jun 23, 2015·FEBS Letters·Takeshi MizuguchiShiv I S Grewal
Aug 12, 2015·PLoS Computational Biology·Jonas PaulsenPhilippe Collas
Mar 10, 2016·Proceedings of the National Academy of Sciences of the United States of America·Harianto TjongFrank Alber
Apr 7, 2017·Cell Biology and Toxicology·Jong Hyun KimDong-Hun Woo
May 4, 2017·Cell Biology and Toxicology·Samantha CorràMaddalena Mognato
Jun 24, 2017·Cell Biology and Toxicology·William WangXiangdong Wang
Sep 15, 2017·Nature·Job DekkerUNKNOWN 4D Nucleome Network
Mar 24, 2018·Cell Biology and Toxicology·Przemyslaw Szalaj, Dariusz Plewczynski
Mar 27, 2018·Cell Biology and Toxicology·Tszshan MaJuntao Gao
Apr 7, 2018·Cell Biology and Toxicology·Takeshi Terabayashi, Katsuhiro Hanada
Apr 25, 2018·Cell Biology and Toxicology·Xiangdong Wang
May 20, 2018·Cell Biology and Toxicology·Yiming ZengXiangdong Wang
May 26, 2018·Cell Biology and Toxicology·Ruifeng LiCheng Li
Jun 9, 2018·Methods : a Companion to Methods in Enzymology·Josée Dostie, Mathieu Blanchette

❮ Previous
Next ❯

Citations

Feb 13, 2019·Cell Biology and Toxicology·Duojiao WuUNKNOWN CSGT group
Feb 3, 2020·Cell Biology and Toxicology·Yiming ZengJiaqiang Zhang
Dec 17, 2019·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Xin CaoXiangdong Wang
Jun 28, 2021·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Lingyue GaoLihui Wang

❮ Previous
Next ❯

Methods Mentioned

BETA
RNA-seq
Hi-C
single-cell Hi-C

Related Concepts

Related Feeds

Alternative splicing

Alternative splicing a regulated gene expression process that allows a single genetic sequence to code for multiple proteins. Here is that latest research.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

Nursing Standard
C Halek
Health Services Journal
E Peck, J Scott
© 2022 Meta ULC. All rights reserved