PMID: 29074838Oct 28, 2017Paper

Genome editing ~Principle and possibility of a novel genetic engineering technology. Basic principles of genome editing

Clinical calcium
Takashi Yamamoto

Abstract

Programmable site-specific nuclease mediated-genome editing is an emerging biotechnology for precise manipulation of target genes. In genome editing, gene-knockout as well as gene-knockin are possible in various organisms and cultured cells. CRISPR-Cas9, which was developed in 2012, is a convenient and efficient programmable site-specific nuclease and the use spreads around the world rapidly. For this, it is important for the progress of life science research to introduce the genome editing technology.

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