Genome organization and transcription strategy in the complex GNS-L intergenic region of bovine ephemeral fever rhabdovirus

The Journal of General Virology
S M McWilliamPeter J Walker

Abstract

A 1622 nucleotide region of the bovine ephemeral fever virus (BEFV) genome, located between the second glycoprotein (GNS) gene and the polymerase (L) gene, has been cloned and sequenced in Australian (BB7721) and Chinese (Beijing-1) isolates of the virus. In the Australian isolate, the region contains five long open reading frames (ORFs) organized into three coding regions (alpha, beta and gamma), each of which are bound by a consensus transcription initiation and transcription termination-polyadenylation-like sequences. The alpha coding region contains three long ORFs (alpha 1, alpha 2 and alpha 3). The alpha 1 ORF encodes a 10.6 kDa polypeptide which contains hydrophobic and highly basic regions characteristic of a viroporin. The alpha 2 ORF encodes a 13.7 kDa polypeptide and overlaps the alpha 3 ORF which encodes a 5.7 kDa polypeptide. The beta coding region contains a single long ORF encoding a polypeptide of 12.2 kDa. The gamma coding region, which does not occur in Adelaide River virus (ARV), contains a single long ORF encoding a polypeptide of 13.4 kDa. The Chinese isolate shares 91% nucleotide sequence identity with the Australian isolate. The organization of the alpha, beta and gamma coding regions is preserved and the...Continue Reading

Citations

Sep 22, 2011·Virus Research·Peter J WalkerKim R Blasdell
Sep 29, 2011·Virus Research·Tomoaki Ogino, Amiya K Banerjee
May 19, 2010·Biochimica Et Biophysica Acta·Kai WangBing Sun
Feb 14, 2015·PLoS Pathogens·Peter J WalkerNikos Vasilakis
May 23, 2009·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·I V KuzminC E Rupprecht
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