Genome organization during the cell cycle: unity in division

Wiley Interdisciplinary Reviews. Systems Biology and Medicine
Rosela GolloshiRachel Patton McCord

Abstract

During the cell cycle, the genome must undergo dramatic changes in structure, from a decondensed, yet highly organized interphase structure to a condensed, generic mitotic chromosome and then back again. For faithful cell division, the genome must be replicated and chromosomes and sister chromatids physically segregated from one another. Throughout these processes, there is feedback and tension between the information-storing role and the physical properties of chromosomes. With a combination of recent techniques in fluorescence microscopy, chromosome conformation capture (Hi-C), biophysical experiments, and computational modeling, we can now attribute mechanisms to many long-observed features of chromosome structure changes during cell division. Apparent conflicts that arise when integrating the concepts from these different proposed mechanisms emphasize that orchestrating chromosome organization during cell division requires a complex system of factors rather than a simple pathway. Cell division is both essential for and threatening to proper genome organization. As interphase three-dimensional (3D) genome structure is quite static at a global level, cell division provides an important window of opportunity to make substantia...Continue Reading

References

Nov 1, 1977·Cell·J R Paulson, U K Laemmli
Aug 5, 1976·Nature·J L Spudich, D E Koshland
May 1, 1985·The Journal of Cell Biology·W C EarnshawL F Liu
Apr 20, 1986·Journal of Molecular Biology·S M GasserU K Laemmli
Jan 1, 1972·Experimental Cell Research·L ZechA Gropp
Jan 1, 1968·Experimental Cell Research·T CasperssonL Zech
Feb 21, 1998·Current Biology : CB·W F MarshallJ W Sedat
Apr 3, 2001·Nature Reviews. Genetics·T Cremer, C Cremer
Apr 24, 2001·Genes & Development·P R PrinceR J Monnat
Feb 16, 2002·Science·Job DekkerNancy Kleckner
Aug 17, 2002·Science·Michael B ElowitzPeter S Swain
Feb 27, 2003·The Journal of Cell Biology·Olivier Cuvier, Tatsuya Hirano
Jun 1, 1964·The Journal of Cell Biology·E ROBBINS, N K GONATAS
Mar 5, 2004·Journal of Cell Science·Ayako Sakaguchi, Akihiko Kikuchi
Nov 23, 2006·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Heiner AlbiezThomas Cremer
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Thomas DechatRobert D Goldman
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Kan CaoFrancis S Collins
Mar 18, 2008·Nature Methods·Igor KireevAndrew S Belmont
Oct 22, 2008·Nature Cell Biology·Hongyan XingKevin D Sarge
Nov 10, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Robert M Martin, M Cristina Cardoso
Dec 17, 2009·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Benjamin D PopeDavid M Gilbert
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Alison GrinthalNancy Kleckner
Mar 3, 2010·The Journal of Cell Biology·Ryo KawamuraJohn F Marko
May 18, 2010·The American Journal of Pathology·Thomas ArendtAndreas Lösche
Jun 10, 2010·The Journal of Cell Biology·Junjie LuDavid M Gilbert
Jul 2, 2010·Cold Spring Harbor Perspectives in Biology·Tom Misteli
Apr 7, 2011·Cold Spring Harbor Symposia on Quantitative Biology·A S BelmontI Kireev
Apr 5, 2012·Nature Reviews. Molecular Cell Biology·Min Sup SongPier Paolo Pandolfi
Apr 25, 2012·Molecular Neurobiology·Thomas Arendt
Aug 14, 2012·Journal of Cellular Physiology·Artem PlissRonald Berezney
Oct 18, 2012·Nucleic Acids Research·Elnaz Alipour, John F Marko
Nov 21, 2012·The Journal of Cell Biology·Kumiko SamejimaWilliam C Earnshaw

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Jul 3, 2021·International Journal of Molecular Sciences·Atiqa SajidMohammed Yusuf

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