Genome packaging in multi-segmented dsRNA viruses: distinct mechanisms with similar outcomes

Current Opinion in Virology
Alexander BorodavkaJohn T Patton

Abstract

Segmented double-stranded (ds)RNA viruses share remarkable similarities in their replication strategy and capsid structure. During virus replication, positive-sense single-stranded (+)RNAs are packaged into procapsids, where they serve as templates for dsRNA synthesis, forming progeny particles containing a complete equimolar set of genome segments. How the +RNAs are recognized and stoichiometrically packaged remains uncertain. Whereas bacteriophages of the Cystoviridae family rely on specific RNA-protein interactions to select appropriate +RNAs for packaging, viruses of the Reoviridae instead rely on specific inter-molecular interactions between +RNAs that guide multi-segmented genome assembly. While these families use distinct mechanisms to direct +RNA packaging, both yield progeny particles with a complete set of genomic dsRNAs.

Citations

Jul 26, 2019·ELife·Yasel Garcés SuárezCarlos F Arias
Nov 20, 2019·Virus Evolution·Anouk Willemsen, Mark P Zwart
Sep 30, 2020·Annual Review of Virology·Yannis Michalakis, Stéphane Blanc
Feb 23, 2020·Nature Chemical Biology·Daniel Luque, José R Castón
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Mar 19, 2020·Chembiochem : a European Journal of Chemical Biology·Nada RaddaouiThomas Carell
Jul 3, 2021·Viruses·Timothy W ThonerKristen M Ogden
Jul 6, 2021·Virus Research·Sarah CaddyUlrich Desselberger
Aug 11, 2021·Viruses·Guido PapaUlrich Desselberger
Sep 16, 2021·The EMBO Journal·Florian GeigerAlexander Borodavka
Oct 8, 2021·Proceedings of the National Academy of Sciences of the United States of America·Jack P K BravoAlexander Borodavka

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Methods Mentioned

BETA
fluorescence correlation spectroscopy

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