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Genome partitioning of genetic variation for complex traits using common SNPs

Nature Genetics

May 10, 2011

J YangP M Visscher

Abstract

We estimate and partition genetic variation for height, body mass index (BMI), von Willebrand factor and QT interval (QTi) using 586,898 SNPs genotyped on 11,586 unrelated individuals. We estimate that ∼45%, ∼17%, ∼25% and ∼21% of the variance in height, BMI, von Willebrand factor and Q...read more

Mentioned in this Paper

Genome-Wide Association Study
CFC1 gene
Chromosomes, Human, X
Polygenic Inheritance
Genetics, Population
Plasma Factor VIII Complex
Lyon Hypothesis
X Chromosome
Body Mass Index Procedure
Von Willebrand's Factor (Lab Test)
7
806
Paper Details
References
  • References41
  • Citations357
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  • References41
  • Citations357
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Genome partitioning of genetic variation for complex traits using common SNPs

Nature Genetics

May 10, 2011

J YangP M Visscher

PMID: 21552263

DOI: 10.1038/ng.823

Abstract

We estimate and partition genetic variation for height, body mass index (BMI), von Willebrand factor and QT interval (QTi) using 586,898 SNPs genotyped on 11,586 unrelated individuals. We estimate that ∼45%, ∼17%, ∼25% and ∼21% of the variance in height, BMI, von Willebrand factor and Q...read more

Mentioned in this Paper

Genome-Wide Association Study
CFC1 gene
Chromosomes, Human, X
Polygenic Inheritance
Genetics, Population
Plasma Factor VIII Complex
Lyon Hypothesis
X Chromosome
Body Mass Index Procedure
Von Willebrand's Factor (Lab Test)
7
806

Feeds With Similar Papers

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Related Papers

American Journal of Human Genetics

Estimating missing heritability for disease from genome-wide association studies

American Journal of Human GeneticsMarch 8, 2011
Sang Hong LeeP M Visscher
American Journal of Human Genetics

GCTA: a tool for genome-wide complex trait analysis

American Journal of Human GeneticsDecember 21, 2010
J YangP M Visscher
Paper Details
References
  • References41
  • Citations357
12345
  • References41
  • Citations357
12345...

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