PMID: 8961554Dec 1, 1996Paper

Genome plasticity in Neisseria gonorrhoeae

FEMS Microbiology Letters
C P Gibbs, T F Meyer

Abstract

The pathogenic Neisseria have exploited the processes of horizontal DNA transfer and genetic recombination as mechanisms for the generation of extensive protein variation and modulation of gene expression. Localized recombinations have been well documented in members of multigene families as have alterations in short repetitive sequences. Here we report an analysis of the chromosomal structure of a defined lineage of Neisseria gonorrhoeae strain MSl1 pilin variants. This study reveals the occurrence of large rearrangements, including the amplification of a 26 kb region and an inversion involving more than a third of the chromosome. Additionally, a restriction site polymorphism that correlates with pilin expression has been observed. These findings highlight the flexibility of the gonococcal genome.

References

Oct 1, 1991·Molecular Microbiology·A BihimaierC P Gibbs
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Jan 1, 1996·Molecular Microbiology·M GäherW Bautsch
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Citations

Feb 1, 2002·FEMS Immunology and Medical Microbiology·Kate L SeibMichael P Jennings
Mar 26, 2008·Sexual Health·David M WhileyJohn W Tapsall
Feb 3, 1999·Annual Review of Genetics·S Casjens
Oct 3, 2012·PloS One·Russell Spencer-SmithLori A S Snyder
Jan 27, 2006·The Journal of Molecular Diagnostics : JMD·David M WhileyTheo P Sloots
Nov 17, 2011·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Vessela Ouzounova-RaykovaIvan Mitov
May 10, 2005·Diagnostic Microbiology and Infectious Disease·David M WhileyTheo P Sloots
Apr 30, 2003·Molecular Genetics and Genomics : MGG·J JoseT F Meyer
Jan 15, 1999·Critical Reviews in Microbiology·C M Kahler, D S Stephens
Nov 3, 2011·Current Protocols in Microbiology·Joseph P Dillard
May 1, 2009·Expert Opinion on Medical Diagnostics·Erik Munson, Marcia A Firmani
Apr 7, 2019·EMBO Reports·Iain D Hay, Trevor Lithgow
Jan 1, 2000·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Søren A Ladefoged
Aug 28, 1999·Journal of Bacteriology·S Stibitz, M S Yang
Jun 25, 2015·Microbiology Spectrum·Kyle P Obergfell, H Steven Seifert

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