Genome rearrangements associated with aberrant telomere maintenance.

Current Opinion in Genetics & Development
Ragini BhargavaRoderick J O'Sullivan

Abstract

There is unequivocal evidence that telomeres are crucial for cellular homeostasis and that telomere dysfunction can elicit genome instability and potentially initiate events that culminate in cancer. Mounting evidence points to telomeres having a crucial role in driving local and systemic structural rearrangements that drive cancer. These include the classical 'breakage-fusion-bridge' (BFB) cycles and more recently identified genome re-shaping events like kataegis and chromothripsis. In this brief review, we outline the established and most recent advances describing the roles that telomere dysfunction has in the origin of these catastrophic genome rearrangements. We discuss how local and systemic structural rearrangements enable telomere length maintenance, by either telomerase or the alternative lengthening of telomeres, that is essential to sustain cancer cell proliferation.

Citations

Sep 18, 2020·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Alejandro D Bolzán
Nov 11, 2020·Epigenetics & Chromatin·Wen-Jun WangJiu-Wei Cui
Jan 23, 2021·Human Molecular Genetics·Chloé SubeczLauréline Roger
Sep 21, 2020·Seminars in Cell & Developmental Biology·Nour L MozaffariAlessandro A Sartori
Nov 3, 2020·DNA Repair·Srijita DharRobert M Brosh
Jul 28, 2021·International Journal of Cancer. Journal International Du Cancer·Sivaramakrishna RachakondaRajiv Kumar
Aug 30, 2021·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Alejandro D Bolzán

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