Genome-scale models of microbial cells: evaluating the consequences of constraints

Nature Reviews. Microbiology
Nathan D PriceBernhard Ø Palsson


Microbial cells operate under governing constraints that limit their range of possible functions. With the availability of annotated genome sequences, it has become possible to reconstruct genome-scale biochemical reaction networks for microorganisms. The imposition of governing constraints on a reconstructed biochemical network leads to the definition of achievable cellular functions. In recent years, a substantial and growing toolbox of computational analysis methods has been developed to study the characteristics and capabilities of microorganisms using a constraint-based reconstruction and analysis (COBRA) approach. This approach provides a biochemically and genetically consistent framework for the generation of hypotheses and the testing of functions of microbial cells.


Feb 2, 1973·Science·P B Weisz
Jan 1, 1984·Bio Systems·M Brumen, R Heinrich
Aug 1, 1993·Applied and Environmental Microbiology·A VarmaBernhard Ø Palsson
Dec 29, 1998·Journal of Bacteriology·M B ElowitzS Leibler
May 1, 1999·Bioinformatics·T PfeifferStefan Schuster
Jun 5, 1999·Biotechnology Progress·Christophe H SchillingR Heinrich
Jun 11, 1999·The Journal of Biological Chemistry·Jeremy S Edwards, Bernhard Ø Palsson
Mar 21, 2000·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·A DanchinP Nitschké
May 11, 2000·Proceedings of the National Academy of Sciences of the United States of America·Jeremy S Edwards, Bernhard Ø Palsson
Sep 23, 2000·BMC Bioinformatics·Jeremy S Edwards, Bernhard Ø Palsson
Dec 2, 2000·Biotechnology Progress·Jeremy S Edwards, Bernhard Ø Palsson
Feb 15, 2001·Nature Biotechnology·Jeremy S EdwardsBernhard Ø Palsson
Mar 3, 2001·Current Opinion in Plant Biology·N Bouché, D Bouchez
Mar 14, 2001·Trends in Biochemical Sciences·Markus W CovertBernhard Ø Palsson
Apr 6, 2001·Biotechnology and Bioengineering·Christophe H SchillingBernhard Ø Palsson
Jun 28, 2001·Biotechnology and Bioengineering·Anthony Burgard, Costas D Maranas
Aug 2, 2001·Journal of Experimental Botany·D ThorneycroftS M Smith
Oct 9, 2001·Trends in Biochemical Sciences·R John Ellis
Nov 16, 2001·Journal of Theoretical Biology·Markus W CovertBernhard Ø Palsson
Dec 18, 2001·Biotechnology and Bioengineering·Jeremy S EdwardsBernhard Ø Palsson
Mar 14, 2002·Current Opinion in Cell Biology·Heng Zhu, Michael Snyder
May 10, 2002·Environmental Microbiology·Jeremy S EdwardsBernhard Ø Palsson
May 15, 2002·The Journal of Biological Chemistry·Markus W Covert, Bernhard Ø Palsson
Jun 8, 2002·Journal of Theoretical Biology·Jason A PapinBernhard Ø Palsson B
Jun 25, 2002·Biophysical Journal·Daniel A BeardHong Qian
Jul 13, 2002·Biotechnology and Bioengineering·Ross CarlsonFriedrich Srienc
Jul 19, 2002·Biophysical Journal·Kenneth J KauffmanJeremy S Edwards
Jul 27, 2002·Journal of Bacteriology·Christophe H SchillingBernhard Ø Palsson
Aug 31, 2002·Biophysical Journal·Radhakrishnan MahadevanFrancis J Doyle
Sep 5, 2002·Biotechnology and Bioengineering·Jochen ForsterJens Nielsen
Sep 21, 2002·Molecular Biology Reports·Steffen Klamt, Jörg Stelling
Nov 5, 2002·Proceedings of the National Academy of Sciences of the United States of America·Daniel SegrèGeorge M Church
Nov 12, 2002·Biophysical Journal·Nathan D PriceBernhard Ø Palsson
Nov 15, 2002·Nature·Jörg StellingErnst Dieter Gilles
Nov 26, 2002·Current Biology : CB·Albertha J M WalhoutMarc Vidal
Nov 28, 2002·Journal of Theoretical Biology·Timothy E Allen, Bernhard Ø Palsson
Dec 6, 2002·Genome Research·Jason A PapinBernhard Ø Palsson
Dec 13, 2002·Nature·Alfred G GilmanParticipating investigators and scientists of the Alliance for Cellular Signaling
Dec 13, 2002·Nature·Joshua LiShankar Subramaniam
Jan 25, 2003·European Journal of Biochemistry·Hong QianShou-dan Liang
Jan 28, 2003·Biophysical Journal·Nathan D PriceBernhard Ø Palsson
Feb 5, 2003·Genome Research·Jochen ForsterJens Nielsen
Mar 19, 2003·Journal of Theoretical Biology·Markus W Covert, Bernhard Ø Palsson
Apr 4, 2003·Biotechnology and Bioengineering·Anthony Burgard, Costas D Maranas
Apr 8, 2003·Trends in Biotechnology·Nathan D PriceBernhard Ø Palsson
Apr 18, 2003·Journal of Bacteriology·Jennifer L Reed, Bernhard Ø Palsson
May 27, 2003·Trends in Biochemical Sciences·Jason A PapinBernhard Ø Palsson
Jun 11, 2003·Recent Progress in Hormone Research·Paul R Graves, Timothy A J Haystead
Jul 25, 2003·Biochimica Et Biophysica Acta·Damien Hall, Allen P Minton
Aug 28, 2003·Journal of Theoretical Biology·Sharon J WibackBernhard Ø Palsson
Sep 4, 2003·Genome Biology·Jennifer L ReedBernhard Ø Palsson
Sep 5, 2003·Nature·R John Ellis, Allen P Minton
Sep 26, 2003·Omics : a Journal of Integrative Biology·Jochen ForsterJens Nielsen
Oct 25, 2003·Journal of Theoretical Biology·Nathan D PriceBernhard Ø Palsson
Oct 28, 2003·Proceedings of the National Academy of Sciences of the United States of America·Iman FamiliBernhard Ø Palsson
Oct 29, 2003·Current Opinion in Biotechnology·Kenneth J KauffmanJeremy S Edwards
Nov 5, 2003·Biotechnology and Bioengineering·Anthony BurgardCostas D Maranas
Dec 4, 2003·Metabolic Engineering·Radhakrishnan Mahadevan, Christophe H Schilling
Jan 7, 2004·Biotechnology and Bioengineering·Markus W CovertBernhard Ø Palsson
Jan 7, 2004·Biotechnology and Bioengineering·Priti PharkyaCostas D Maranas
Jan 14, 2004·Genome Research·Anthony BurgardCostas D Maranas
Mar 26, 2004·Nature Reviews. Microbiology·D R Lovley
Apr 27, 2004·Omics : a Journal of Integrative Biology·Anu RaghunathanEugene Kolker
May 7, 2004·Nature·Markus W CovertBernhard Ø Palsson
Jun 5, 2004·Journal of Theoretical Biology·Sharon J WibackBernhard Ø Palsson
Jul 9, 2004·Biophysical Journal·Jason A Papin, Bernhard Ø Palsson
Jul 31, 2004·Trends in Biotechnology·Jason A PapinBernhard Ø Palsson
Feb 1, 1984·Biotechnology and Bioengineering·Eleftherios T Papoutsakis
Mar 25, 1990·Biotechnology and Bioengineering·R A Majewski, M M Domach
Feb 20, 1994·Biotechnology and Bioengineering·A Varma, Bernhard Ø Palsson


Mar 15, 2008·Applied Microbiology and Biotechnology·Sang Yup LeeYu-Sin Jang
Nov 19, 2008·Applied Microbiology and Biotechnology·Cong T TrinhFriedrich Srienc
Nov 29, 2012·Applied Microbiology and Biotechnology·Chuan XuMing Chen
Apr 24, 2013·Journal of Industrial Microbiology & Biotechnology·Rasmus AgrenJens Nielsen
Aug 1, 2012·Antonie van Leeuwenhoek·Cuauhtemoc Licona-CassaniLars Keld Nielsen
Oct 1, 2006·Journal of Biological Physics·Frank J Bruggeman, Hans V Westerhoff
Nov 10, 2012·Applied Biochemistry and Biotechnology·Sohila Zadran, Raphael D Levine
Apr 16, 2005·Current Opinion in Biotechnology·Eddy J SmidBas Teusink
Jun 1, 2005·Trends in Biotechnology·Sang Yup LeeTae Yong Kim
Aug 6, 2011·Journal of Proteome Research·Yoshihiro ToyaMasaru Tomita
Aug 20, 2008·Nature Biotechnology·Tomer ShlomiEytan Ruppin
Mar 10, 2010·Nature Biotechnology·Jeffrey D OrthBernhard Ø Palsson
Oct 13, 2006·Nature Biotechnology·Sang Yup Lee
Jun 10, 2008·Nature Biotechnology·Adam M Feist, Bernhard Ø Palsson
Dec 17, 2009·Nature Cell Biology·Honghong HuJulian I Schroeder
Oct 22, 2008·Nature Chemical Biology·Richard Bonneau
Oct 27, 2010·Nature Chemical Biology·Bernhard Ø Palsson, Karsten Zengler
May 31, 2011·Nature Genetics·Balázs SzappanosBalázs Papp
Apr 5, 2007·Nature Protocols·Scott A BeckerMarkus J Herrgård
Sep 3, 2011·Nature Protocols·Jan SchellenbergerBernhard Ø Palsson
Sep 21, 2013·Nature Reviews. Genetics·Koyel MitraTrey Ideker
Jan 1, 2009·Nature Reviews. Microbiology·Adam M FeistBernhard Ø Palsson
Mar 3, 2009·Nature Reviews. Microbiology·Tie KoideNitin S Baliga
Nov 23, 2007·Natural Product Reports·J Stefan RokemJens Nielsen
Aug 19, 2007·Molecular BioSystems·Monica L MoBernhard Ø Palsson
Jul 5, 2008·Proceedings of the National Academy of Sciences of the United States of America·D-S LeeA-L Barabási
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Andrew M WierMargaret J McFall-Ngai
Aug 4, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jong Myoung ParkSang Yup Lee
Sep 30, 2010·Proceedings of the National Academy of Sciences of the United States of America·Sriram Chandrasekaran, Nathan D Price
Jul 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·John P DeLongJames H Brown
Apr 6, 2011·Proceedings of the National Academy of Sciences of the United States of America·Zhi Wang, Jianzhi Zhang
Apr 18, 2012·Proceedings of the National Academy of Sciences of the United States of America·Aditya BarveAndreas Wagner
Jan 12, 2010·Antioxidants & Redox Signaling·Lars M BlankBruno Bühler
Feb 6, 2009·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Balaji Veeramani, Joel S Bader
Feb 4, 2012·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Liram VardiRoded Sharan
Apr 26, 2008·Briefings in Bioinformatics·Francisco J Planes, John E Beasley
Mar 17, 2009·Briefings in Bioinformatics·Karthik Raman, Nagasuma Chandra
Mar 7, 2012·Briefings in Bioinformatics·Gurkan BebekMark R Chance
Sep 29, 2005·Bioinformatics·R Urbanczik, Clemens Wagner
Aug 5, 2008·Bioinformatics·Marco Terzer, Jörg Stelling
May 30, 2009·Bioinformatics·Shira Mintz-OronTomer Shlomi
Oct 2, 2009·Bioinformatics·Luís F de FigueiredoFrancisco J Planes
May 27, 2010·Bioinformatics·Florian CentlerPeter Dittrich
Nov 18, 2010·Bioinformatics·Hadas ZurTomer Shlomi
Dec 15, 2010·Bioinformatics·Alberto RezolaFrancisco J Planes
Dec 23, 2011·Bioinformatics·Kathrin BallersteinUtz-Uwe Haus
Feb 8, 2013·Bioinformatics·Arne C Müller, Alexander Bockmayr
Jul 3, 2013·Bioinformatics·Rodrigo Liberal, John W Pinney
Aug 13, 2013·Database : the Journal of Biological Databases and Curation·Benjamin D HeavnerLarry P Walker
Jan 1, 2009·Genome Biology and Evolution·Zhi Wang, Jianzhi Zhang
Mar 2, 2012·Journal of Experimental Botany·Xuewen Chen, Yair Shachar-Hill
Sep 15, 2006·Journal of the Royal Society, Interface·Francis J Doyle, Jörg Stelling
Aug 17, 2012·Journal of the Royal Society, Interface·Moritz Emanuel BeberMarc-Thorsten Hütt
Oct 6, 2005·Genome Research·Lars KuepferLars M Blank
Jan 2, 2010·Plant Physiology·Cristiana Gomes de Oliveira Dal'MolinLars Keld Nielsen
May 5, 2012·Science·Robert SchuetzUwe Sauer
Mar 30, 2010·Applied and Environmental Microbiology·Hyung Seok ChoiHan Min Woo
Apr 7, 2009·Applied and Environmental Microbiology·Margreet I PastinkJeroen Hugenholtz
Aug 31, 2010·Applied and Environmental Microbiology·Han Min WooMichael Bott
Oct 3, 2006·Journal of Bacteriology·Andrew R JoyceSanjay Agarwalla
Apr 2, 2013·Annual Review of Chemical and Biomolecular Engineering·Benjamin M WoolstonGregory Stephanopoulos
Feb 9, 2008·Annual Review of Plant Biology·Igor G L Libourel, Yair Shachar-Hill
Jan 1, 2010·Journal of Biomedicine & Biotechnology·Jennifer L ReedJamey D Young
Feb 28, 2009·BMC Bioinformatics·Yanping XiFei Wang
Apr 30, 2010·BMC Bioinformatics·Jan SchellenbergerBernhard Ø Palsson
Apr 25, 2012·BMC Bioinformatics·Abdelhalim LarhlimiAlexander Bockmayr
Mar 24, 2006·BMC Bioinformatics·Kazuharu ArakawaMasaru Tomita
Jun 15, 2006·BMC Bioinformatics·Richard A NotebaartBas Teusink
Nov 25, 2006·BMC Bioinformatics·Anne KümmelMatthias Heinemann
Feb 9, 2006·BMC Bioinformatics·Steffen KlamtErnst Dieter Gilles
Apr 28, 2007·BMC Bioinformatics·Matthew DeJonghAaron Best
Jan 26, 2008·BMC Bioinformatics·Erwin P GianchandaniJason A Papin
Mar 27, 2010·BMC Genomics·Mohammad Tauqeer AlamRainer Breitling
Aug 19, 2006·Biology Direct·Alex A NeyfakhLev J Mizrokhi
Apr 6, 2007·BMC Systems Biology·Steffen KlamtErnst Dieter Gilles
Jul 21, 2007·BMC Systems Biology·Hiroyuki KurataKazuyuki Shimizu
Apr 6, 2007·BMC Systems Biology·Christoph GilleHermann-Georg Holzhütter
May 2, 2008·BMC Systems Biology·Marcin Imielinski, Calin Belta
May 30, 2008·BMC Systems Biology·Julio R Banga
Jul 1, 2008·BMC Systems Biology·Jeremiah Wright, Andreas Wagner
Jul 12, 2008·BMC Systems Biology·Jeremiah Wright, Andreas Wagner
Jan 25, 2008·BMC Systems Biology·Alexei VazquezZ N Oltvai
Oct 31, 2009·BMC Systems Biology·Esa PitkänenJuho Rousu
Dec 22, 2009·BMC Systems Biology·Bevan Kai Sheng Chung, Dong-Yup Lee
Mar 10, 2009·BMC Systems Biology·Christian L BarrettBernhard Ø Palsson
Mar 27, 2009·BMC Systems Biology·Monica L MoMarkus J Herrgård
May 19, 2009·BMC Systems Biology·Seth B RobertsGregory A Buck
Sep 3, 2010·BMC Systems Biology·Carola HuthmacherHermann-Georg Holzhütter
Oct 21, 2010·BMC Systems Biology·Martin I SigurdssonBernhard Ø Palsson
Dec 25, 2010·BMC Systems Biology·Jun SunD R Lovley
Mar 23, 2010·BMC Systems Biology·Areejit SamalAndreas Wagner
Jan 30, 2010·BMC Systems Biology·Kieran SmallbonePedro Mendes
Feb 4, 2010·BMC Systems Biology·Stacey D FinleyVassily Hatzimanikatis
Jul 16, 2010·BMC Systems Biology·Balaji Veeramani, Joel S Bader
Aug 26, 2011·BMC Systems Biology·Areejit SamalOlivier C Martin
Mar 17, 2011·BMC Systems Biology·Nikolaus SonnenscheinMarc-Thorsten Hütt
Sep 27, 2012·BMC Systems Biology·David ByrneDaniel Segrè
May 16, 2012·BMC Systems Biology·Nikolaus SonnenscheinMarc-Thorsten Hütt
Jun 6, 2012·BMC Systems Biology·Benjamin D HeavnerLarry P Walker
Jun 19, 2012·BMC Systems Biology·Amornpan KlanchuiAsawin Meechai
Jun 21, 2012·BMC Systems Biology·Dave LeeNeil Swainston
Feb 1, 2012·BMC Systems Biology·Jan SchellenbergerBernhard Ø Palsson
Nov 15, 2013·BMC Systems Biology·Gabriel Gelius-DietrichMartin J Lercher
Jul 24, 2013·BMC Systems Biology·Francisco G Vital-LopezJaques Reifman
Mar 9, 2006·Genome Biology·Brendan Thomason, Timothy D Read
Apr 20, 2010·Genome Biology·Tomer BenyaminiTomer Shlomi
Dec 15, 2012·Genome Biology·Christopher J Tervo, Jennifer L Reed
May 29, 2012·Genome Biology·Sung Ho YoonJihyun F Kim
Jun 29, 2005·Journal of Biology·Markus J Herrgård, Bernhard Ø Palsson
Dec 20, 2005·PLoS Computational Biology·Eivind AlmaasAlbert-László Barabási
May 20, 2006·PLoS Computational Biology·Christian L Barrett, Bernhard Ø Palsson
Jul 15, 2006·PLoS Computational Biology·Markus J HerrgårdBernhard Ø Palsson
Aug 10, 2006·PLoS Computational Biology·Erwin P GianchandaniBernhard Ø Palsson
Aug 29, 2007·PLoS Computational Biology·Julio Saez-RodriguezBurkhart Schraven
Oct 10, 2007·PLoS Computational Biology·Osbaldo Resendis-AntonioBernhard Ø Palsson
Jan 30, 2008·PLoS Computational Biology·Richard A NotebaartBalázs Papp
May 17, 2008·PLoS Computational Biology·Scott A Becker, Bernhard Ø Palsson
May 17, 2008·PLoS Computational Biology·Jong Min LeeJason A Papin
Dec 6, 2008·PLoS Computational Biology·Takashi NishikawaAdilson E Motter
Feb 21, 2009·PLoS Computational Biology·Fan LiBernhard Ø Palsson
Jun 9, 2009·PLoS Computational Biology·Erwin P GianchandaniJason A Papin
Jun 13, 2009·PLoS Computational Biology·Bas TeusinkEddy J Smid
Aug 8, 2009·PLoS Computational Biology·Regina SamagaSteffen Klamt
Dec 4, 2009·PLoS Computational Biology·Albert A de GraafBen van Ommen
Dec 19, 2009·PLoS Computational Biology·João F Matias Rodrigues, Andreas Wagner
Sep 3, 2010·PLoS Computational Biology·M Ahsanul IslamRadhakrishnan Mahadevan
Nov 10, 2010·PLoS Computational Biology·Dipak BaruaJennifer L Reed
Nov 8, 2012·PLoS Computational Biology·Markus KraussLars Kuepfer
Nov 8, 2012·PLoS Computational Biology·Ana Rita BrochadoKiran Raosaheb Patil
Dec 19, 2013·PLoS Computational Biology·Sriram Chandrasekaran, Nathan D Price
Jan 24, 2014·PLoS Computational Biology·Nikos VlassisThomas Sauter
Mar 4, 2014·PLoS Computational Biology·Anupam ChowdhuryCostas D Maranas
May 17, 2014·PLoS Computational Biology·Lei XiePhilip E Bourne
Dec 31, 2009·PLoS Genetics·Marina SirotaAtul J Butte
Sep 3, 2010·PloS One·Osbaldo Resendis-AntonioSergio Encarnación
Jul 23, 2011·PloS One·Areejit Samal, Olivier C Martin
Apr 24, 2012·PloS One·Gunnar SigurdssonInes Thiele
Jul 7, 2012·PloS One·Tugce Bilgin, Andreas Wagner
Jun 7, 2013·PloS One·Ruchir A KhandelwalFrank J Bruggeman
Sep 25, 2010·PLoS Pathogens·Claudia PommerenkeSusanne Häussler
Jun 6, 2009·HFSP Journal·Balázs PappRichard A Notebaart
Nov 15, 2011·Bioanalysis·Maria Elena MerloRainer Breitling
Aug 28, 2010·Genetics and Molecular Research : GMR·J SchneiderA Goesmann
Jul 2, 2010·Chaos·Marcin Imielinski, Calin Belta
Dec 17, 2005·Proceedings of the National Academy of Sciences of the United States of America·Christian L BarrettBernhard Ø Palsson
Sep 22, 2012·Advances in Bioinformatics·J Paul BrooksSeth B Roberts
Nov 29, 2007·Proceedings of the National Academy of Sciences of the United States of America·Carsten ConradiJörg Stelling
Feb 3, 2007·Proceedings of the National Academy of Sciences of the United States of America·Natalie C DuarteBernhard Ø Palsson
Apr 12, 2014·Genome Biology·Benjamin VanderSluisAmy A Caudy
Feb 8, 2007·Proceedings of the National Academy of Sciences of the United States of America·Richard HarrisonDaniela Delneri
Jul 27, 2007·Proceedings of the National Academy of Sciences of the United States of America·Q K BegZ N Oltvai
Jul 30, 2014·Proceedings of the National Academy of Sciences of the United States of America·Richard A NotebaartBalázs Papp
Oct 27, 2009·Acta Biotheoretica·Philippe De BackerLinda Van Speybroeck
Aug 27, 2013·Applied Microbiology and Biotechnology·Nicolas A L FlahautWillem M de Vos
Oct 22, 2013·Journal of Mathematical Biology·Arne C Müller, Alexander Bockmayr
Oct 26, 2012·Advances in Bioinformatics·Amine GhozlanePatricia Thébault
May 14, 2014·Advances in Bioinformatics·Rajadurai Chinnasamy PerumalGopal Ramesh Kumar
Aug 16, 2013·Briefings in Bioinformatics·Liam G FearnleyLars K Nielsen
Jan 13, 2006·Nature Chemical Biology·Stephen S FongBernhard Ø Palsson
Sep 21, 2010·Nature Chemical Biology·Dan S Tawfik
Sep 1, 2009·Metabolomics : Official Journal of the Metabolomic Society·Tunahan CakırAge K Smilde
Dec 1, 2009·Expert Opinion on Drug Discovery·Nagasuma Chandra
Jan 16, 2016·Molecular Biology and Evolution·Ildikó KarcagiBalázs Papp
Feb 6, 2014·Critical Reviews in Biotechnology·Murillo L ButionGláucia M Pastore
Sep 23, 2009·FEBS Letters·Bernhard Ø Palsson
Oct 27, 2009·FEBS Letters·Jens Nielsen
Dec 17, 2014·Microbial Cell Factories·Kiyotaka Y HaraAkihiko Kondo
Apr 28, 2010·FEBS Letters·Liming LiuJens Nielsen
Jan 3, 2016·Journal of Biotechnology·Rafael S CostaSusana Vinga
Sep 16, 2015·Proceedings of the National Academy of Sciences of the United States of America·Wout MegchelenbrinkRichard A Notebaart
Dec 10, 2015·Bioprocess and Biosystems Engineering·Roberto GallardoGermán Aroca
Oct 30, 2012·Current Opinion in Biotechnology·Ines ThieleRonan M T Fleming
Oct 9, 2012·Journal of Bioscience and Bioengineering·Satoshi OhnoHiroshi Shimizu
May 30, 2012·Journal of Biotechnology·Pieter-Jan D'HuysKristel Bernaerts
Aug 19, 2011·Biotechnology Advances·Tobias OsterlundJens Nielsen
Aug 30, 2011·Trends in Microbiology·Christopher M Gowen, Stephen S Fong
Jun 29, 2011·Bio Systems·Abdelhalim LarhlimiZoran Nikoloski
May 20, 2011·Current Opinion in Biotechnology·Matthew Scott, Terence Hwa
Feb 5, 2011·Current Opinion in Structural Biology·Lei XiePhilip E Bourne
Sep 8, 2010·Mathematical Biosciences·Yun Lee, Eberhard O Voit
Aug 24, 2010·Trends in Biotechnology·Keng Cher Soh, Vassily Hatzimanikatis
Aug 10, 2010·Current Opinion in Biotechnology·Eytan RuppinStefan Schuster
May 1, 2010·Current Opinion in Microbiology·Adam M Feist, Bernhard Ø Palsson
Apr 10, 2010·Current Opinion in Microbiology·Keng Cher Soh, Vassily Hatzimanikatis
Dec 2, 2009·Molecular Phylogenetics and Evolution·Mohammad Tauqeer AlamRainer Breitling
Dec 8, 2009·Bio Systems·Vicente AcuñaLeen Stougie
Nov 3, 2009·Trends in Ecology & Evolution·Bastien Boussau, Vincent Daubin
Aug 28, 2009·Current Opinion in Microbiology·Véronique de BerardinisMarcel Salanoubat
Dec 5, 2015·Biophysical Journal·Liliana Angeles-Martinez, Constantinos Theodoropoulos
Jun 23, 2009·Journal of Theoretical Biology·Ettore MurabitoJonathan Swinton
Jul 21, 2009·Journal of Biotechnology·Dina Petranovic, Goutham N Vemuri
May 26, 2009·Biotechnology Advances·Jong Myoung ParkSang Yup Lee
Nov 18, 2008·Trends in Biotechnology·Monica L Mo, Bernhard Ø Palsson
Nov 11, 2008·Current Opinion in Biotechnology·Sung Kuk LeeJay D Keasling
Sep 9, 2008·Drug Discovery Today·Sang Yup LeeTae Yong Kim
Jul 23, 2008·Metabolic Engineering·Mounir IzallalenD R Lovley
Jun 28, 2008·Trends in Biotechnology·Jin Hwan ParkHyun Uk Kim
Dec 5, 2015·The ISME Journal·Francisca C GarcíaÁngel López-Urrutia
Sep 18, 2007·Progress in Biophysics and Molecular Biology·Jacob D FealaAndrew D McCulloch
Aug 8, 2007·Current Opinion in Biotechnology·Nathan D Price, Ilya Shmulevich
May 19, 2007·Current Opinion in Biotechnology·Katherine D McMahonPhilip Hugenholtz
Jun 15, 2007·Phytochemistry·Rigoberto Rios-Estepa, Bernd Markus Lange
Nov 23, 2006·Trends in Microbiology·Frank J Bruggeman, Hans V Westerhoff
Oct 16, 2015·Drug Discovery Today. Technologies·Hans V WesterhoffMatteo Barberis
Oct 27, 2015·Frontiers in Microbiology·Neema Jamshidi, Anu Raghunathan
Mar 13, 2016·Briefings in Functional Genomics·Zeyad Abd AlgfoorHoshang Kolivand
Apr 9, 2005·Environmental Microbiology·D R Lovley
May 8, 2009·Biotechnology and Bioengineering·Hong YangMarianthi G Ierapetritou
May 9, 2009·Plant, Cell & Environment·Doug K AllenYair Shachar-Hill
Feb 17, 2009·Biotechnology and Bioengineering·Juan-Carlos Rodríguez-PradosMarta Cascante
Sep 14, 2010·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Marco TerzerJörg Stelling
Jul 3, 2009·Biotechnology Progress·Young-Gyun OhSunwon Park
Apr 1, 2008·Annals of the New York Academy of Sciences·Jacob D FealaAndrew D McCulloch
Jan 17, 2008·Molecular Systems Biology·Steffen KlamtErnst Dieter Gilles
Mar 6, 2008·Molecular Systems Biology·Neema Jamshidi, Bernhard Ø Palsson
Aug 20, 2009·Molecular Systems Biology·Tomoaki MatsuuraTetsuya Yomo
Oct 17, 2006·Molecular Microbiology·Sigrid C J De KeersmaeckerKathleen Marchal
Mar 14, 2007·Evolution; International Journal of Organic Evolution·Christian O Marks
Apr 4, 2007·Biotechnology and Bioengineering·Tae Yong KimSang Yup Lee
Jun 6, 2009·Journal of Theoretical Biology·Kieran Smallbone, Evangelos Simeonidis
Apr 30, 2009·Molecular Systems Biology·Tomer ShlomiEytan Ruppin
Oct 10, 2007·The FEBS Journal·Kieran SmallboneDouglas B Kell
Sep 14, 2010·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Bas TeusinkFrank J Bruggeman
Jun 23, 2011·Molecular Systems Biology·Ori FolgerTomer Shlomi
Jan 19, 2012·Biotechnology and Bioengineering·Suresh SelvarasuDong-Yup Lee
Jul 11, 2012·The FEBS Journal·Juliane GebauerChristoph Kaleta
Jan 17, 2012·Proteomics·Tzu-Chiao Chao, Nicole Hansmeier
Jan 3, 2013·Environmental Microbiology·Gal Winter, Jens O Krömer
Mar 23, 2013·Biotechnology Journal·Kai ZhuangMarkus J Herrgård
Jul 29, 2010·Biotechnology Journal·Brian J SchmidtJason A Papin
Jul 31, 2013·Biotechnology Journal·Timo R MaarleveldFrank J Bruggeman
Apr 4, 2013·Molecular Systems Biology·Judith A H WodkeTobias Maier
Aug 15, 2012·Biotechnology Journal·Christoph Knuf, Jens Nielsen
May 2, 2013·Molecular Systems Biology·D McCloskeyAdam M Feist
Apr 1, 2011·Molecular Systems Biology·Keren YizhakEytan Ruppin
Apr 25, 2013·Biotechnology Journal·Adil MardinogluJens Nielsen
Sep 9, 2010·Molecular Systems Biology·Germán PlataDennis Vitkup
Mar 11, 2010·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Sven Dietz, Sven Panke
Oct 24, 2013·Environmental Microbiology·Joshua J Hamilton, Jennifer L Reed
Apr 15, 2014·British Journal of Clinical Pharmacology·Marc-Thorsten Hütt
Sep 14, 2010·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Lucas B EdelmanNathan D Price
Jul 29, 2010·Biotechnology Journal·Fahimeh SalimiRadhakrishnan Mahadevan
Dec 1, 2009·Biotechnology Journal·Caroline B MilneNathan D Price
Nov 13, 2010·IEEE/ACM Transactions on Computational Biology and Bioinformatics·Rogier J P van BerloMarcel J T Reinders
Nov 6, 2007·Biophysical Journal·Radhakrishnan Mahadevan, D R Lovley
Sep 12, 2006·Current Opinion in Biotechnology·Douglas RidgwayMichael J Ellison
Aug 29, 2006·Current Opinion in Biotechnology·Christian L BarrettSang Yup Lee
Apr 18, 2006·Trends in Biochemical Sciences·Erwin P GianchandaniJason A Papin
Mar 15, 2006·Blood Cells, Molecules & Diseases·Neema Jamshidi, Bernhard Ø Palsson
Mar 1, 2015·Briefings in Bioinformatics·Aarthi Ravikrishnan, Karthik Raman
May 13, 2006·Microbes and Infection·Helena I M Boshoff, Ujjini H Manjunatha
Sep 20, 2005·Trends in Microbiology·Christof FranckeBas Teusink
Dec 7, 2005·Biochemical Pharmacology·John D Trawick, Christophe H Schilling
Oct 24, 2015·BioMed Research International·Xueying ChenHong Qu
Apr 8, 2016·Current Opinion in Microbiology·Herwig BachmannBas Teusink
Jan 1, 2005·Biophysical Journal·Iman FamiliBernhard Ø Palsson
Nov 26, 2010·Science·Joshua Lerman, Bernhard Ø Palsson
Nov 3, 2015·Plant, Cell & Environment·Xin-Guang ZhuStephen P Long
Jun 13, 2015·World Journal of Microbiology & Biotechnology·Predrag HorvatGerhart Braunegg
May 28, 2015·Trends in Cell Biology·James A EddyNathan D Price
Dec 11, 2008·FEMS Microbiology Reviews·Maxime DurotVincent Schachter
Oct 15, 2013·FEMS Microbiology Reviews·Sara E Blumer-SchuetteRobert M Kelly
Jan 1, 2010·Annual Review of Food Science and Technology·Eddy J Smid, Jeroen Hugenholtz
Jan 8, 2015·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Arne C ReimersLeen Stougie
Jan 12, 2010·Trends in Biochemical Sciences·Nana-Maria GrüningMarkus Ralser
Nov 9, 2014·Human Genetics·Donald GemanLaurent Younes
Nov 8, 2014·Computational and Structural Biotechnology Journal·Min Kyung Kim, Desmond S Lun
Nov 8, 2014·Computational and Structural Biotechnology Journal·Stephen S Fong
Jun 12, 2012·Plant Science : an International Journal of Experimental Plant Biology·Eva CollakovaRyan S Senger
Apr 22, 2014·Seminars in Cancer Biology·Osbaldo Resendis-AntonioCarlos Felipe Salgado-Muñoz
Dec 19, 2006·Biophysical Journal·Christopher S HenryVassily Hatzimanikatis
May 23, 2006·Biophysical Journal·Tihamér Geyer, Volkhard Helms
Feb 2, 2011·Biophysical Journal·Jan SchellenbergerBernhard Ø Palsson
Sep 27, 2005·Biophysical Journal·Clemens Wagner, R Urbanczik
Mar 15, 2014·Briefings in Bioinformatics·Alberto RezolaFrancisco J Planes
Aug 3, 2013·Proceedings of the National Academy of Sciences of the United States of America·Piyush LabhsetwarZaida Luthey-Schulten
Aug 31, 2007·FEMS Yeast Research·Jens Nielsen, Michael C Jewett
Nov 30, 2014·Genome Biology and Evolution·Djordje BajićJuan F Poyatos
Oct 13, 2015·PloS One·Wout MegchelenbrinkElena Marchiori
Jun 3, 2016·Integrative and Comparative Biology·Erin S Morrison, Alexander V Badyaev
Dec 3, 2015·PloS One·Miguel Ponce-de-LeonFrancisco Montero
Apr 8, 2015·PLoS Computational Biology·Timo R MaarleveldFrank J Bruggeman
Oct 21, 2014·PLoS Computational Biology·Matthew N BenedictNathan D Price
Feb 27, 2010·Journal of Biotechnology·Kwee-Yan Teh, Andrew E Lutz
Mar 23, 2010·Metabolic Engineering·Sergio Bordel, Jens Nielsen
Sep 22, 2016·FEMS Yeast Research·Moshe KafriNaama Barkai
Aug 8, 2014·PloS One·Matthew A RichardsNathan D Price
Mar 4, 2017·Interdisciplinary Sciences, Computational Life Sciences·Jorge FerreiraMiguel Rocha
Jul 11, 2007·Expert Review of Molecular Diagnostics·Douglas B Kell
Dec 22, 2009·Molecular BioSystems·Suresh SelvarasuDong-Yup Lee
May 23, 2015·Integrative Biology : Quantitative Biosciences From Nano to Macro·M Ahsanul IslamGregory Stephanopoulos
Aug 17, 2012·Scientific Reports·Steven M KelkFrank J Bruggeman
Nov 7, 2017·Molecular Biology and Evolution·Sergey V Venev, Konstantin B Zeldovich
Jan 1, 2012·Metabolites·Nikolaus SonnenscheinMarc-Thorsten Hütt
Mar 31, 2006·Nature·Csaba PálLaurence D Hurst
Dec 1, 2017·Journal of the Royal Society, Interface·Hidde de JongJean-Luc Gouzé
Nov 29, 2005·Nature Genetics·Csaba PálMartin J Lercher
Aug 3, 2011·Nature Reviews. Genetics·Balázs PappCsaba Pál
May 16, 2017·Mathematical Medicine and Biology : a Journal of the IMA·Benjamin EngelhardtHolger Fröhlich
Sep 4, 2014·Microbiology and Molecular Biology Reviews : MMBR·Joana C XavierIsabel Rocha
Sep 27, 2018·FEMS Microbiology Letters·Ilyas KabimoldayevDonghyuk Kim
May 21, 2016·Nature Communications·Balázs SzappanosBalázs Papp
Oct 21, 2016·Nature Communications·Jeanne M O Eloundou-MbebiZoran Nikoloski
Jun 30, 2006·Biotechnology and Bioengineering·Qiang HuaBernhard Ø Palsson
Jun 22, 2006·Molecular Systems Biology·Steve Van Dien, Christophe H Schilling
Jul 6, 2006·Molecular Systems Biology·Neema Jamshidi, Bernhard Ø Palsson
Oct 7, 2006·Nature·Barbara Di VenturaLuis Serrano
Oct 4, 2006·Molecular Systems Biology·Tunahan CakirJens Nielsen
Nov 15, 2006·Molecular Systems Biology·Uwe Sauer
Mar 14, 2007·Molecular Systems Biology·Sergey StolyarDavid A Stahl
Jul 13, 2007·Molecular Systems Biology·Jens Nielsen
Nov 21, 2007·Nature Reviews. Microbiology·Rainer BreitlingMichael P Barrett
May 27, 2006·Molecular Systems Biology·George M Church
Feb 5, 2008·Biotechnology Journal·Tae Yong KimSang Yup Lee
Nov 23, 2007·Journal of Cellular and Molecular Medicine·Nathan D PriceQiang Tian
Jul 8, 2008·Nature Reviews. Microbiology·James K FredricksonJames M Tiedje
Sep 17, 2009·Molecular BioSystems·Josselin NoirelPhillip C Wright
Nov 6, 2009·Molecular Systems Biology·Douwe MolenaarBas Teusink
Mar 1, 2019·PLoS Computational Biology·Chiara DamianiGiancarlo Mauri
Jan 19, 2006·Nature Reviews. Genetics·Jennifer L ReedBernhard Ø Palsson
Feb 24, 2006·Nature Reviews. Molecular Cell Biology·Andrew R Joyce, Bernhard Ø Palsson
Dec 17, 2005·Nature Reviews. Microbiology·Bas Teusink, Eddy J Smid
Jun 2, 2006·Molecular Systems Biology·Adam M FeistTrey Ideker
Aug 4, 2006·American Journal of Physiology. Cell Physiology·Thuy D Vo, Bernhard Ø Palsson
Mar 25, 2014·Nature Reviews. Microbiology·Victor ChubukovUwe Sauer
Mar 28, 2012·Nature Reviews. Microbiology·Karsten Zengler, Bernhard Ø Palsson
Aug 7, 2007·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Thomas Wilhelm
May 9, 2019·PloS One·Anamya Ajjolli NagarajaFrederic Cadet
Jan 24, 2012·Nature Reviews. Microbiology·Marnix H MedemaRainer Breitling
Jun 14, 2016·Scientific Reports·Rui JiangAlexander Golberg
Feb 17, 2010·Bioscience·Yufeng Wang, Timothy G Lilburn
Jan 1, 2010·Biotechnology & Genetic Engineering Reviews·Tomer Shlomi
Jun 16, 2012·Molecular BioSystems·Swagatika SahooInes Thiele
Jun 19, 2013·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Shalini SinghSanjay Jain
Nov 30, 2018·Molecular Systems Biology·Felix MoserChristopher A Voigt
Jul 20, 2012·Journal of Bioinformatics and Computational Biology·Ali CakmakGultekin Ozsoyoglu
May 31, 2019·Biotechnology Journal·Brendan Fu-Long SieowMatthew Wook Chang
Aug 3, 2017·Applied Microbiology and Biotechnology·Kun DaiRaymond J Zeng
Sep 25, 2010·Biochemical Society Transactions·Evangelos SimeonidisHans V Westerhoff
Nov 29, 2015·Biochemical Society Transactions·Arne C Reimers
Nov 29, 2015·Biochemical Society Transactions·Stefan SchusterChristoph Kaleta
Jan 28, 2020·PLoS Computational Biology·Daan H de GrootRobert Planqué
Oct 26, 2006·The Journal of Biological Chemistry·Bas TeusinkEddy J Smid
Jan 24, 2008·Molecular BioSystems·Hyun Uk KimSang Yup Lee
Sep 28, 2017·Biotechnology for Biofuels·Areejit SamalN Louise Glass
Feb 5, 2020·Annual Review of Plant Biology·Teresa J ClarkJorg Schwender
Jun 25, 2020·Proteomics·Sanjeev DahalLaurence Yang
Oct 23, 2016·BMC Systems Biology·Sayed-Rzgar Hosseini, Andreas Wagner
Oct 23, 2008·The Journal of Biological Chemistry·Jan Schellenberger, Bernhard Ø Palsson
Jan 5, 2011·Protein & Cell·Liu-Yan ZhangJing Wang
Aug 2, 2018·Nature Communications·Erez PersiEytan Ruppin
May 10, 2019·NPJ Systems Biology and Applications·Matteo MoriAndrea De Martino
Sep 23, 2020·Nature Reviews. Microbiology·Xin FangBernhard Ø Palsson
Jan 31, 2017·Archaea : an International Microbiological Journal·ShengShee ThorZaida Luthey-Schulten
Jan 1, 2016·Journal of the Royal Society, Interface·Willi GottsteinBas Teusink
Jan 31, 2019·Metabolites·Partho Sen, Matej Orešič
Apr 26, 2019·International Journal of Molecular Sciences·A Suggey Guerra-RenteriaOrfil González-Reynoso
May 21, 2019·Frontiers in Microbiology·Alvaro FuertesFrancisco J Planes
Sep 25, 2010·Biochemical Society Transactions·Igor Goryanin
Jan 30, 2018·Frontiers in Molecular Biosciences·Partho SenMatej Orešič
Nov 25, 2016·BMC Genomics·Marco FondiRenato Fani
Jul 4, 2018·Scientific Reports·Aarthi RavikrishnanKarthik Raman
Mar 29, 2018·Biochemical Society Transactions·Martin H Rau, Ahmad A Zeidan
Nov 30, 2019·Scientific Reports·Rotem KatzirEytan Ruppin
Oct 27, 2017·FEMS Microbiology Reviews·Kristina Klobucar, Eric D Brown
Nov 27, 2018·Royal Society Open Science·Mauricio Moreno-ZambranoMarc-Thorsten Hütt
Sep 13, 2019·Bioinformatics·Reza MiraskarshahiLeonid Chindelevitch
Oct 7, 2020·Nature Communications·Amin Espah BorujeniChristopher A Voigt
Dec 10, 2020·Biotechnology & Genetic Engineering Reviews·Shreya AnandPadmini Padmanabhan
Dec 2, 2004·The Journal of Biological Chemistry·Ines ThieleBernhard Ø Palsson
Jan 10, 2021·Nature Communications·Gang LiJens Nielsen

Related Concepts

Computer Programs and Programming
Systems Theory
Genome, Bacterial
Bacterial Physiological Phenomena
Computational Molecular Biology

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Daniel SegrèGeorge M Church
Nature Reviews. Genetics
Jennifer L ReedBernhard Ø Palsson
Current Opinion in Biotechnology
Kenneth J KauffmanJeremy S Edwards
© 2021 Meta ULC. All rights reserved