Genome scan for loci regulating HDL cholesterol levels in Finnish extended pedigrees with early coronary heart disease.

European Journal of Human Genetics : EJHG
Tiia Kangas-KontioMarkku J Savolainen

Abstract

Coronary heart disease (CHD) is the leading cause of mortality in Western societies. Its risk is inversely correlated with plasma high-density lipoprotein cholesterol (HDL-C) levels, and approximately 50% of the variability in these levels is genetically determined. In this study, the aim was to carry out a whole-genome scan for the loci regulating plasma HDL-C levels in 35 well-defined Finnish extended pedigrees (375 members genotyped) with probands having low HDL-C levels and premature CHD. The additive genetic heritability of HDL-C was 43%. A variance component analysis revealed four suggestive quantitative trait loci (QTLs) for HDL-C levels, with the highest LOD score, 3.1, at the chromosomal locus 4p12. Other suggestive LOD scores were 2.1 at 2q33, 2.1 at 6p24 and 2.0 at 17q25. Three suggestive loci for the qualitative low HDL-C trait were found, with a nonparametric multipoint score of 2.6 at the chromosomal locus 10p15.3, 2.5 at 22q11 and 2.1 at 6p12. After correction for statin use, the strongest evidence of linkage was shown on chromosomes 4p12, 6p24, 6p12, 15q22 and 22q11. To search for the underlying gene on chromosome 6, we analyzed two functional and positional candidate genes (peroxisome proliferator-activated rec...Continue Reading

References

May 23, 1998·American Journal of Human Genetics·L Almasy, J Blangero
Jun 23, 1998·American Journal of Human Genetics·J R O'Connell, D E Weeks
Mar 19, 1999·Journal of Internal Medicine·A O RantalaY A Kesäniemi
Sep 2, 1999·Human Molecular Genetics·L PeltonenT Varilo
May 20, 2000·FEBS Letters·M D LeibowitzJ Auwerx
Aug 5, 2000·Biochemical and Biophysical Research Communications·K SchwartzD P Wade
Sep 23, 2000·Nature·A J Lusis
Apr 20, 2001·Proceedings of the National Academy of Sciences of the United States of America·W R OliverT M Willson
Aug 29, 2001·Bioinformatics·G R AbecasisL R Cardon
Nov 10, 2001·Arteriosclerosis, Thrombosis, and Vascular Biology·J M PeacockG Heiss
Dec 4, 2001·Nature Genetics·Gonçalo R AbecasisLon R Cardon
Feb 18, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·M C MahaneyJ W MacCluer
Jul 16, 2003·The American Journal of Cardiology·Peter H JonesUNKNOWN STELLAR Study Group
Feb 21, 2004·BMC Genetics·Rector AryaUNKNOWN Framingham Heart Study
May 11, 2004·Human Heredity·Ethan M Lange, Kenneth Lange
Jun 3, 2004·Current Opinion in Genetics & Development·Teppo Varilo, Leena Peltonen
Jun 5, 2004·Atherosclerosis·Toni I PollinBraxton D Mitchell
Jul 20, 2004·Journal of Lipid Research·Heidi E LiljaPäivi Pajukanta
Jan 8, 2005·Circulation Research·Xiaosong Wang, Beverly Paigen
Mar 5, 2005·Bioinformatics·Nandita MukhopadhyayDaniel E Weeks
Dec 3, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Zari DastaniPäivi Pajukanta
Mar 4, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Zhiyong LinMukesh K Jain
Dec 13, 2006·American Journal of Hypertension·Chin-Fu HsiaoUNKNOWN SAPPHIRe Study Group

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.