Genome sequence analysis of emm89 Streptococcus pyogenes strains causing infections in Scotland, 2010-2016

Journal of Medical Microbiology
Stephen B BeresJames M Musser

Abstract

Strains of type emm89 Streptococcus pyogenes have recently increased in frequency as a cause of human infections in several countries in Europe and North America. This increase has been molecular epidemiologically linked with the emergence of a new genetically distinct clone, designated clade 3. We sought to extend our understanding of this epidemic behavior by the genetic characterization of type emm89 strains responsible in recent years for an increased frequency of infections in Scotland. We sequenced the genomes of a retrospective cohort of 122 emm89 strains recovered from patients with invasive and noninvasive infections throughout Scotland during 2010 to 2016. All but one of the 122 emm89 infection isolates are of the recently emerged epidemic clade 3 clonal lineage. The Scotland isolates are closely related to and not genetically distinct from recent emm89 strains from England, they constitute a single genetic population. The clade 3 clone causes virtually all-contemporary emm89 infections in Scotland. These findings add Scotland to a growing list of countries of Europe and North America where, by whole genome sequencing, emm89 clade 3 strains have been demonstrated to be the cause of an ongoing epidemic of invasive infe...Continue Reading

References

Aug 16, 2018·Epidemiology and Infection·Timothy C BarnettJonathan R Carapetis

Citations

Oct 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·M R WesselsT J DiCesare
Feb 26, 2000·Infection and Immunity·G L DarmstadtC E Rubens
Oct 14, 2005·Molecular Biology and Evolution·Daniel H Huson, David Bryant
Oct 29, 2005·The Lancet Infectious Diseases·Jonathan R CarapetisMartin Weber
Jul 20, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jessica DarenbergBirgitta Henriques Normark
Aug 30, 2007·PloS One·Stephen B Beres, James M Musser
Sep 7, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Rosalyn E O'LoughlinActive Bacterial Core Surveillance Team
Nov 17, 2007·Epidemiology and Infection·G FalkenhorstK Mølbak
Jan 23, 2009·Journal of Clinical Microbiology·Bogdan Luca-HarariAftab Jasir
Jan 30, 2010·Bioinformatics·Aaron R Quinlan, Ira M Hall
Feb 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Stephen B BeresJames M Musser
Mar 30, 2010·Trends in Microbiology·Pierre R SmeestersKadaba S Sriprakash
Jun 22, 2010·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·T SiljanderJ Vuopio
Mar 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Patrick R SheaJames M Musser
Aug 31, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·S RantalaJ Syrjänen
Sep 3, 2011·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·C PlainvertCNR-Strep network
Oct 7, 2011·Journal of Clinical Microbiology·A LepoutreMicrobiologists of the Epibac Network
Oct 18, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·S VähäkuopusJ Vuopio
Nov 22, 2011·Emerging Infectious Diseases·Patrick R SheaJames M Musser
Apr 4, 2012·Emerging Infectious Diseases·Nahuel FittipaldiJames M Musser
Apr 18, 2012·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Anton BankevichPavel A Pevzner
Jul 12, 2012·Systematic Biology·Daniel H Huson, Celine Scornavacca
Sep 4, 2013·The Journal of Infection·Esther TamayoEmilio Pérez-Trallero
Oct 12, 2013·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Ying-Mei LiuBin Cao
Apr 4, 2014·Bioinformatics·Anthony M BolgerBjoern Usadel
Apr 16, 2014·Proceedings of the National Academy of Sciences of the United States of America·Waleed NasserJames M Musser
May 7, 2014·The Journal of Infectious Diseases·Martina Sanderson-SmithM Protein Study Group
May 14, 2014·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·L B OlafsdottirMagnus Gottfredsson
Jul 2, 2014·Journal of Medical Microbiology·Nathalie M KarakySima T Tokajian
Sep 26, 2014·Journal of Clinical Microbiology·Randall J OlsenJames M Musser
Nov 22, 2014·Nucleic Acids Research·Nicholas J CroucherSimon R Harris
Nov 26, 2014·Genome Medicine·Michael InouyeKathryn E Holt
Dec 3, 2014·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·C PlainvertC Poyart
Feb 24, 2015·Epidemiology and Infection·T IkebeWorking Group for Beta-haemolytic Streptococci in Japan
Aug 11, 2015·The Journal of Clinical Investigation·Luchang ZhuJames M Musser
Aug 22, 2015·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·P W SmitJ Vuopio

Related Concepts

Bacterial Proteins
Genome
Clone
Sequence Analysis
Comparative Genomic Analysis
Genetic Epidemiology
Bacteria, Flesh-Eating
Sequence Determinations, DNA
Streptococcal Infections
Streptococcus pyogenes

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