Genome-sequence analysis of the pathogenic H5N1 avian influenza A virus isolated in China in 2004

Virus Genes
Hongbo ZhouZhengjun Yu

Abstract

Analysis of the sequences of the genome of the avian influenza A/chicken/Hubei/327/2004 (H5N1) virus, isolated from a poultry farm during the outbreak of avian influenza (AI) in Hubei Province, central China, in the spring of 2004, revealed that the hemagglutinin (HA) gene of the virus was genetically similar to those of the H5 highly pathogenic avian influenza virus (HPAI). Notably, the neuraminidase gene of the virus had a 20-amino acid deletion in the stalk region and a 5-amino acid deletion in the NS gene which belonged to allele B. Furthermore, the internal genes (PB2, PA, NP, M2) of the A/chicken/Hubei/327/2004 virus with the particular amino acid residues were more closely related to H5N1 viruses of 2000-2003 isolated in Hong Kong and the AIV of Thailand and Vietnam in 2004, but less likely to evolve from the viruses of Hong Kong 1997. Finally, our results demonstrated that the influenza A/chicken/Hubei/327/2004 (H5N1) virus was similar to those of the AI viruses isolated from Hong Kong (2000-2003), Vietnam, and Thailand rather than the viruses from the 1997 lineage of Hong Kong and with closest genetic relatives to the influenza A/Chicken/Hong Kong/61.9/02 (H5N1) virus. These data suggest that the influenza A/chicken/Hu...Continue Reading

References

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Citations

Sep 5, 2008·Annual Review of Genomics and Human Genetics·Xiaonan YangGuo-Ping Zhao
Dec 17, 2009·The Journal of Veterinary Medical Science·Sakar ShivakotiToshihiro Ito
Mar 21, 2008·Molecular Phylogenetics and Evolution·Geoff Vana, Kristi M Westover
Mar 22, 2008·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·R Kurth, S Glasmacher
Mar 28, 2009·International Journal of Molecular Sciences·Mary E Christopher, Jonathan P Wong
Dec 1, 2009·Indian Journal of Microbiology·James E Hollenbeck
Dec 24, 2019·Zoonoses and Public Health·Jayaveeramuthu NirmalaMontserrat Torremorell
Sep 16, 2018·Viruses·Ahmed MostafaStephan Pleschka
Jan 8, 2021·Frontiers in Veterinary Science·Wenxiao GongMeilin Jin

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