Abstract
Salmonella enterica serovar Infantis (S. Infantis) is one of the dominant serovars of the bacterial pathogen S. enterica. In recent years, the number of human infections caused by S. Infantis has been increasing in many countries, and often the emerging population harbors a unique virulence-resistant megaplasmid called plasmid of emerging S. Infantis (pESI). Here, we report the complete gap-free genome sequence of the S. Infantis Israeli emerging clone and compare its chromosome and pESI sequences with other complete S. Infantis genomes. We show a conserved presence of the Salmonella pathogenicity islands 1-6, 9, 11, 12, and CS54 and a common integration of five bacteriophages in the S. Infantis chromosome. In contrast, we found variable presence of additionally three chromosomally integrated phages and eight modular regions in pESI, which contribute to the genetic and phenotypic diversity (including antimicrobial resistance) of this ubiquitous foodborne pathogen.
References
Oct 9, 2004·Journal of Clinical Microbiology·Ernesto LiebanaJaime Martinez-Urtaza
Feb 28, 2007·Antimicrobial Agents and Chemotherapy·Axel CloeckaertFrançois-Xavier Weill
Jul 16, 2008·FEMS Immunology and Medical Microbiology·Ian L Ross, Michael W Heuzenroeder
Aug 19, 2008·International Journal of Food Microbiology·N NógrádyI Kiss
Jun 12, 2009·Bioinformatics·Anna I RissmanNicole T Perna
Aug 12, 2009·Veterinary Microbiology·Francis ShahadaKaroku Okamoto
Oct 30, 2010·Emerging Infectious Diseases·Ohad Gal-MorIsrael Nissan
Jun 7, 2011·Microbial Ecology·Annika JacobsenCarsten Friis
Aug 10, 2011·BMC Genomics·Nabil-Fareed AlikhanScott A Beatson
Mar 10, 2012·Foodborne Pathogens and Disease·Elisabeth HauserBurkhard Malorny
Dec 11, 2013·Environmental Microbiology·Gili AvivOhad Gal-Mor
Dec 30, 2014·Veterinary Microbiology·Eiji YokoyamaSatoshi Murakami
Dec 4, 2015·PLoS Medicine·Arie H HavelaarUNKNOWN World Health Organization Foodborne Disease Burden Epidemiology Reference Group
Dec 31, 2015·PloS One·Alessia FrancoAntonio Battisti
May 5, 2016·Nucleic Acids Research·David ArndtDavid S Wishart
Sep 8, 2016·MBio·Gili AvivOhad Gal-Mor
May 10, 2017·Antimicrobial Agents and Chemotherapy·Heather TateShaohua Zhao
Jun 9, 2017·PLoS Computational Biology·Ryan R WickKathryn E Holt
Jul 22, 2017·Genome Announcements·Andrés IriarteFrancisco García-Del Portillo
Jul 29, 2017·Frontiers in Microbiology·Denise HindermannMagdalena Nüesch-Inderbinen
Aug 18, 2017·PLoS Pathogens·Gili AvivOhad Gal-Mor
Jan 26, 2018·Food Microbiology·Ama SzmolkaBéla Nagy
May 8, 2019·The Journal of Infectious Diseases·Gili AvivOhad Gal-Mor
Oct 28, 2019·Microbiology Resource Announcements·Katherine Vallejos-SánchezManolo Fernández-Díaz
Nov 16, 2019·BMC Genomics·Pernille GymoeseEva Litrup
Jan 14, 2020·International Journal of Food Microbiology·Alexandra N BogomazovaAlexander A Komarov
Citations
Aug 9, 2020·Frontiers in Microbiology·Silvia García-SotoUlrich Methner
Nov 3, 2020·Frontiers in Veterinary Science·Lorena MejíaChristian Vinueza-Burgos
Nov 25, 2020·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Gregory H TysonShaohua Zhao
Jul 2, 2021·Emerging Microbes & Infections·Victoria DrauchClaudia Hess
Aug 20, 2021·Open Forum Infectious Diseases·Nkuchia M M'ikanathaDeepanker Tewari
Oct 26, 2021·Microbial Genomics·Michael PietschAntje Flieger