Mar 21, 2016

Genome sequence of tsetse bracoviruses: insights into symbiotic virus evolution

BioRxiv : the Preprint Server for Biology
Kelvin M KimenyiBenard W Kulohoma

Abstract

Mutualism between endogenous viruses and eukaryotes is still poorly understood. Whole genome data has highlighted the diverse distribution of viral sequences in several eukaryote host genomes. A group of endogenous double-stranded polydnaviruses known as bracoviruses has been identified in parasitic braconid wasp (Hymenoptera). Bracoviruses allow wasps to reproductively co-opt other insect larvae. Bracoviruses are excised from the host genome and injected in to the larva along side the wasp eggs; where they encode proteins that lower host immunity allowing development of parasitoid wasp larvae in the host. Interestingly, putative bracoviral sequences have recently been detected in the first sequenced genome of the tsetse fly (Diptera). This is peculiar since tsetse flies do not share this reproductive lifestyle. To investigate genome rearrangements associated with these unique mutual symbiotic relationships and examine its value as a potential vector control strategy entry point. We use comparative genomics to determine the presence, prevalence and genetic diversity of bracoviruses of five tsetse fly species (G. austeni, G. brevipalpis, G. f. fuscipes, G. m. morsitans and G. pallidipes) and the housefly (Musca domestica). We id...Continue Reading

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Mentioned in this Paper

Glossina
WAS gene
Virus
Genome
Genes
Genome Assembly Sequence
Genes, Viral
Phylogenetic Analysis
Hepatitis B Virus
Musca domestica (invertebrate)

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