Genome Size Affects Fitness in the Eukaryotic Alga Dunaliella tertiolecta.

Current Biology : CB
Martino E MalerbaDustin J Marshall

Abstract

Genome size is tightly coupled to morphology, ecology, and evolution among species [1-5], with one of the best-known patterns being the relationship between cell size and genome size [6, 7]. Classic theories, such as the "selfish DNA hypothesis," posit that accumulating redundant DNA has fitness costs but that larger cells can tolerate larger genomes, leading to a positive relationship between cell size and genome size [8, 9]. Yet the evidence for fitness costs associated with relatively larger genomes remains circumstantial. Here, we estimated the relationships between genome size, cell size, energy fluxes, and fitness across 72 independent lineages in a eukaryotic phytoplankton. Lineages with relatively smaller genomes had higher fitness, in terms of both maximum growth rate and total biovolume reached at carrying capacity, but paradoxically, they also had lower energy fluxes than lineages with relative larger genomes. We then explored the evolutionary trajectories of absolute genome size over 100 generations and across a 10-fold change in cell size. Despite consistent directional selection across all lineages, genome size decreased by 11% in lineages with absolutely larger genomes but showed little evolution in lineages with...Continue Reading

References

Aug 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·K P BaetckeS S Schwemmer
Apr 17, 1980·Nature·W F Doolittle, C Sapienza
Apr 17, 1980·Nature·L E Orgel, F H Crick
May 20, 1999·Proceedings. Biological Sciences·R O Deaner, C L Nunn
Apr 3, 2001·Applied and Environmental Microbiology·D K Button, B R Robertson
Apr 28, 2001·Biological Reviews of the Cambridge Philosophical Society·T R Gregory
Mar 27, 2002·Evolution; International Journal of Organic Evolution·T Ryan Gregory
Oct 31, 2003·Trends in Genetics : TIG·Alexander E Vinogradov
Aug 13, 2004·Proceedings. Biological Sciences·Alexander E Vinogradov
Dec 15, 2004·Annals of Botany·Charles A KnightDmitri A Petrov
Dec 14, 2005·American Journal of Physical Anthropology·Sandra ThorénPeter M Kappeler
May 24, 2006·Cytogenetic and Genome Research·G JovtchevI Schubert
Jan 6, 2007·The New Phytologist·Jeremy M BeaulieuCharles A Knight
Apr 11, 2007·Genome Research·Matthew J OliverOscar M Schofield
Jun 29, 2007·Molecular Biology of the Cell·Paul JorgensenBruce Futcher
Nov 14, 2007·The Journal of Cell Biology·Frank R Neumann, Paul Nurse
Mar 1, 1949·Evolution; International Journal of Organic Evolution·J B S HALDANE
Dec 29, 2011·Proceedings of the National Academy of Sciences of the United States of America·Christopher P KempesMichael J Follows
Jun 30, 2012·Nature Methods·Johannes SchindelinAlbert Cardona
Jul 26, 2014·Annual Review of Marine Science·Emilio Marañón
Sep 10, 2014·Evolution; International Journal of Organic Evolution·Charles L Nunn, Natalie Cooper
Jul 5, 2016·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·Masaomi KurokawaBei-Wen Ying
Sep 22, 2016·PeerJ·Maud I TenaillonClaude Welcker
Feb 1, 1997·Evolution; International Journal of Organic Evolution·Alexander E Vinogradov
Sep 25, 2017·Ecology·Martino E MalerbaDustin J Marshall
Nov 17, 2017·Ecology Letters·Martino E MalerbaDustin J Marshall
Feb 15, 2018·Genes·Jaume PellicerIlia J Leitch
Apr 17, 2018·The New Phytologist·Martino E MalerbaDustin J Marshall
Nov 19, 2019·The American Naturalist·Molly C WomackKim L Hoke
Dec 10, 2019·Evolution; International Journal of Organic Evolution·Martino E Malerba, Dustin J Marshall

❮ Previous
Next ❯

Citations

Nov 7, 2020·The New Phytologist·Martino E MalerbaJohn Beardall

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.