Genome-wide analysis of DNA methylation in an APP/PS1 mouse model of Alzheimer's disease

Acta neurologica Belgica
Lin CongYongxin Sun

Abstract

To investigate aberrant genome-wide CpG methylation patterns in cortex brain tissue of APP/PS1 mice and as compared to controls, which allows for identification of novel disease-associated genes. This study investigates the genome-wide DNA methylation profiles of the cortex from APP/PS1 transgenic mice and control mice using the Roche NimbleGen chip platform. Functional analysis was then conducted by Ingenuity Pathways Analysis system. The methylated DNA fragments in the genome of each sample were enriched by MeDIP and the whole-genome interrogations were hybridized to the Roche NimbleGen Human DNA Methylation 3x720 K CpG Island Plus RefSeq Promoter Array that cover 15,980 CpG islands and 20,404 reference gene promoter regions of the entire human genome. Analysis reveals 2346 CpG sites representing 485 unique genes as potentially associated with AD disease status pending confirmation in additional study. At the same time, these hyper-methylated genes display familial aggregation. An impairment of the transforming growth factor-β1 (TGF-β1) signaling pathway has been demonstrated to be specific to the AD brain and, particularly, to the early phase of the disease, supporting a role for epigenetic change of TGF-β1 in AD pathology. ...Continue Reading

References

Jan 1, 1997·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·I RäihäL Sourander
Jun 20, 2000·Neurobiology of Aging·H AkiyamaT Wyss-Coray
Mar 29, 2001·Physiological Reviews·D J Selkoe
May 8, 2004·Trends in Biochemical Sciences·Peter ten Dijke, Caroline S Hill
Oct 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Aravind SubramanianJill P Mesirov
Mar 23, 2006·Annual Review of Immunology·Ming O LiRichard A Flavell
Oct 19, 2006·Reproductive Toxicology·Dana C DolinoyRandy L Jirtle
Nov 1, 2006·The European Journal of Neuroscience·Uwe UeberhamThomas Arendt
Nov 3, 2006·The Journal of Clinical Investigation·Ina TesseurTony Wyss-Coray
Feb 7, 2007·Journal of Neuropathology and Experimental Neurology·Katy A Chalmers, Seth Love
Mar 17, 2007·Nature Reviews. Genetics·Randy L Jirtle, Michael K Skinner
Jun 22, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Laure VerretClaire Rampon
Sep 19, 2008·Genome Biology·Yong ZhangX Shirley Liu
Jul 17, 2009·Journal of Neuropathology and Experimental Neurology·Marta Barrachina, Isidre Ferrer
Nov 21, 2009·CNS Neuroscience & Therapeutics·Filippo CaraciAgata Copani
Jan 26, 2010·Progress in Neurobiology·Leonidas ChouliarasDaniel L A van den Hove
Apr 10, 2010·Journal of Applied Physiology·Oscar AguileraMario F Fraga
Jul 9, 2010·Nature·Alika K MaunakeaJoseph F Costello
Nov 19, 2010·The Journal of Nutrition, Health & Aging·B JuraskovaJ Krejsek
Mar 8, 2011·Nucleic Acids Research·Seung-Gi JinGerd P Pfeifer
Apr 13, 2011·Neurobiology of Aging·Diego MastroeniJoseph Rogers
Sep 1, 2011·Cell and Tissue Research·Filippo CaraciAgata Copani

❮ Previous
Next ❯

Citations

Jan 7, 2016·Frontiers in Behavioral Neuroscience·Jose V Sanchez-Mut, Johannes Gräff
Oct 27, 2016·Scientific Reports·Iben DaugaardLise Lotte Hansen
May 12, 2018·Molecular Medicine Reports·Jong-Min ParkYoun-Jung Kim
Jan 17, 2017·Molecular Neurobiology·Talal Jamil QaziHong Qing
Feb 13, 2019·Translational Neuroscience·Leonidas ChouliarasDaniel L A van den Hove
Nov 9, 2017·Molecular and Cellular Neurosciences·Roy LardenoijeBart P F Rutten

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.

Alzheimer's Disease: Animal Models

Alzheimer's disease is a neurodegenerative disease which can be studied using various experimental systems. This feed focuses on animal models used for Alzheimer's disease research.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Cell Signaling & Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. This feed covers the latest research on signaling and epigenetics in cell growth and cancer.