Genome-wide analysis of Excretory/Secretory proteins in Trypanosoma brucei brucei: Insights into functional characteristics and identification of potential targets by immunoinformatics approach

Genomics
Gowdham ManivelShanmughavel Piramanayagam

Abstract

Trypanosoma brucei brucei (T.b.brucei) is an extra-cellular parasite that causes Animal African Trypanosomiasis (AAT) disease in animals. Till day, this disease is more difficult to treat and control due to lack of efficient vaccines and early diagnosis of the parasite infection. T.b.brucei Excretory/Secretory (ES) proteins were involved in pathogenesis and key for understanding the host-parasite interactions. Functions of T.b.brucei's ES proteins were poorly investigated and experimental identification is expensive and time-consuming. Bioinformatics approaches are cost-effective by facilitating the experimental analysis of potential drug targets for parasitic diseases. Here we applied several bioinformatics tools to predict and functionalize the annotation of 1104 ES proteins and immunoinformatics approaches carried out to predict and evaluate the epitopes in T.b.brucei. Secretory information, functional annotations and potential epitopes of each ES proteins were available at http://tbb.insilico.in. This study provides functional information of T.b.brucei for experimental studies to identify potential targets for diagnosis and therapeutics development.

References

Dec 10, 1990·FEBS Letters·A S Kolaskar, P C Tongaonkar
Jun 15, 1990·Biochemical and Biophysical Research Communications·L V ReddyJ E Donelson
Aug 1, 1981·Tropical Animal Health and Production·A A Ilemobade, T F Balogun
Feb 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·M A HorwitzG Harth
Aug 2, 1996·The Journal of Biological Chemistry·J D BangsJ L Roggy
Oct 18, 1996·Molecular and Biochemical Parasitology·V B CarruthersG A Cross
May 9, 1998·Molecular and Biochemical Parasitology·J E DonelsonN M El-Sayed
Dec 11, 1999·Nucleic Acids Research·M Kanehisa, S Goto
Jul 13, 2000·Journal of Molecular Biology·O EmanuelssonG von Heijne
Jan 30, 2002·Molecular and Biochemical Parasitology·Herlinde GerritsPiet Borst
Mar 7, 2003·Nature·Luc VanhammeEtienne Pays
Sep 19, 2003·International Journal for Parasitology·Peter J HotezPhilip K Russell
Apr 23, 2004·Expert Opinion on Biological Therapy·Angelika L Bonin-DebsUlrich Brinkmann
Apr 30, 2004·Protein Engineering, Design & Selection : PEDS·Jannick Dyrløv BendtsenSøren Brunak
Jun 10, 2004·Microbiology and Molecular Biology Reviews : MMBR·Harold TjalsmaJan Maarten van Dijl
Sep 27, 2006·Protein Science : a Publication of the Protein Society·Pernille Haste AndersenOle Lund
Dec 5, 2006·Anais Da Academia Brasileira De Ciências·Philippe Vincendeau, Bernard Bouteille
Jan 9, 2007·BMC Bioinformatics·Irini A Doytchinova, Darren R Flower
Oct 4, 2007·BMC Structural Biology·Julia V Ponomarenko, Philip E Bourne
Feb 16, 2008·Parasites & Vectors·Dietmar Steverding
May 1, 2008·Nucleic Acids Research·Stefan GötzAna Conesa
May 17, 2008·International Journal of Plant Genomics·Ana Conesa, Stefan Götz
May 2, 2009·Molecular and Biochemical Parasitology·James P HewitsonRick M Maizels
Jul 21, 2009·Fungal Genetics and Biology : FG & B·Adrian TsangScott E Baker
Dec 17, 2009·Journal of Biomedicine & Biotechnology·Celestine Michelle Atyame NtenAnne Geiger
Jul 22, 2010·Trends in Parasitology·Richard J Wheeler
Oct 1, 2011·Nature Methods·Thomas Nordahl PetersenHenrik Nielsen
Dec 20, 2011·Microbes and Infection·Paul McVeighMark W Robinson

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Citations

May 24, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Víctor Caña-BozadaF Neptalí Morales-Serna

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