Genome-wide analysis of retinal transcriptome reveals common genetic network underlying perception of contrast and optical defocus detection.

BMC Medical Genomics
Tatiana V Tkatchenko, Andrei V Tkatchenko

Abstract

Refractive eye development is regulated by optical defocus in a process of emmetropization. Excessive exposure to negative optical defocus often leads to the development of myopia. However, it is still largely unknown how optical defocus is detected by the retina. Here, we used genome-wide RNA-sequencing to conduct analysis of the retinal gene expression network underlying contrast perception and refractive eye development. We report that the genetic network subserving contrast perception plays an important role in optical defocus detection and emmetropization. Our results demonstrate an interaction between contrast perception, the retinal circadian clock pathway and the signaling pathway underlying optical defocus detection. We also observe that the relative majority of genes causing human myopia are involved in the processing of optical defocus. Together, our results support the hypothesis that optical defocus is perceived by the retina using contrast as a proxy and provide new insights into molecular signaling underlying refractive eye development.

References

Mar 3, 1977·Nature·T N Wiesel, E Raviola
Jan 1, 1990·Ciba Foundation Symposium·E Raviola, T N Wiesel
Jan 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·R A StoneT N Wiesel
Jan 1, 1988·Vision Research·F SchaeffelH C Howland
Aug 1, 1987·Current Eye Research·D TroiloJ Wallman
Nov 1, 1974·Vision Research·R BlakeM L Crawford
Jan 1, 1984·Vision Research·H M PetryV A Casagrande
Jan 1, 1982·Current Eye Research·M S Banks
May 1, 1995·Visual Neuroscience·J B Calderone, G H Jacobs
Nov 1, 1994·Neuron·P RöhlichA Szél
Aug 1, 1993·Biological Reviews of the Cambridge Philosophical Society·G H Jacobs
Jul 1, 1993·Optometry and Vision Science : Official Publication of the American Academy of Optometry·I Geer, K M Robertson
Aug 1, 1997·Vision Research·K L Schmid, C F Wildsoet
Sep 8, 1998·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·D A AtchisonA Bradley
May 26, 1999·Vision Research·L GianfranceschiL Maffei
Aug 18, 1999·Proceedings of the National Academy of Sciences of the United States of America·S MessagerP J Morgan
Oct 6, 1999·Current Biology : CB·G Neves, L Lagnado
Oct 8, 1999·American Journal of Ophthalmology·R Pararajasegaram
Feb 9, 2000·Vision Research·V PorciattiL Maffei
Sep 22, 2001·American Journal of Human Genetics·K MachinisS Amselem
Mar 6, 2002·The European Journal of Neuroscience·Henriette S NielsenJan Fahrenkrug

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Software Mentioned

Ingenuity Pathway Analysis , QIAGEN
DAVID
GOplot R package
OptoMotry
UCSC Table Browser
IPA Pathways Activity Analysis
Partek
StatSoft
STAR aligner
LDlink

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