Genome-wide analysis of the Drosophila immune response by using oligonucleotide microarrays

Proceedings of the National Academy of Sciences of the United States of America
E De GregorioB Lemaitre

Abstract

To identify new Drosophila genes involved in the immune response, we monitored the gene expression profile of adult flies in response to microbial infection by using high-density oligonucleotide microarrays encompassing nearly the full Drosophila genome. Of 13,197 genes tested, we have characterized 230 induced and 170 repressed by microbial infection, most of which had not previously been associated with the immune response. Many of these genes can be assigned to specific aspects of the immune response, including recognition, phagocytosis, coagulation, melanization, activation of NF-kappaB transcription factors, synthesis of antimicrobial peptides, production of reactive oxygen species, and regulation of iron metabolism. Additionally, we found a large number of genes with unknown function that may be involved in control and execution of the immune response. Determining the function of these genes represents an important challenge for improving our knowledge of innate immunity. Complete results may be found at http://www.fruitfly.org/expression/immunity/.

References

Jul 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·W J LeeP T Brey
Feb 7, 1998·Proceedings of the National Academy of Sciences of the United States of America·B LemaitreJ A Hoffmann
Apr 2, 1998·Current Opinion in Immunology·K Söderhäll, L Cerenius
Aug 26, 1998·Proceedings of the National Academy of Sciences of the United States of America·D KangH Steiner
Sep 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·S Uttenweiler-JosephP Bulet
Dec 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·M B EisenD Botstein
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·M HallK Söderhäll
Oct 20, 1999·Cellular and Molecular Life Sciences : CMLS·C R Dearolf
Mar 25, 2000·Science·M D AdamsJ C Venter
Mar 24, 2000·Science·G M RubinS Lewis
Jun 7, 2000·Proceedings of the National Academy of Sciences of the United States of America·G DimopoulosF C Kafatos
Sep 6, 2000·Proceedings of the National Academy of Sciences of the United States of America·S TauszigJ L Imler
Oct 12, 2000·Proceedings of the National Academy of Sciences of the United States of America·M LagueuxJ A Hoffmann
Oct 26, 2000·Trends in Genetics : TIG·R S Khush, B Lemaitre
Dec 6, 2000·Proceedings of the National Academy of Sciences of the United States of America·T WernerD Hultmark
Jan 11, 2000·Biochemical and Biophysical Research Communications·M HedengrenD Hultmark
Apr 27, 2001·Trends in Immunology·U Mahlknecht, G Herbein
Apr 27, 2001·Trends in Immunology·R S KhushB Lemaitre
Aug 1, 1997·Trends in Cell Biology·J A Hergannan, J V Rechhart

❮ Previous
Next ❯

Citations

Nov 15, 2006·Journal of Molecular Evolution·Francis M Jiggins, Kang-Wook Kim
Sep 5, 2012·Molecular Genetics and Genomics : MGG·Punya NachappaCecilia Tamborindeguy
Mar 12, 2004·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Yanyuan BaoIsao Morishima
Dec 31, 2003·Molecular Immunology·Silvia Naitza, Petros Ligoxygakis
May 3, 2003·Biochemical and Biophysical Research Communications·Evy VierstraeteLiliane Schoofs
Nov 6, 2002·Journal of Invertebrate Pathology·Robert M OuedraogoMichael J Bidochka
Dec 24, 2002·Current Opinion in Immunology·Dan Hultmark
Sep 27, 2002·Current Opinion in Pharmacology·Sanjay Tickoo, Steven Russell
Mar 6, 2003·Gene Expression Patterns : GEP·Zakaria KambrisMaria Capovilla
Mar 8, 2003·Parasitology·A R KraaijeveldH C J Godfray
Oct 20, 2007·Nature Reviews. Immunology·Dominique FerrandonJules A Hoffmann
Jun 18, 2002·Cellular Microbiology·Carlos P SilvaRichard H ffrench-Constant
Jun 28, 2008·Proceedings of the National Academy of Sciences of the United States of America·Georgios ChamilosDimitrios P Kontoyiannis
Nov 16, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jianming ChenJiahuai Han
Feb 23, 2012·Proceedings of the National Academy of Sciences of the United States of America·Andrew J PetersenDavid A Wassarman
Aug 1, 2012·Proceedings of the National Academy of Sciences of the United States of America·Minglin LangMaureen J Gorman
Jul 14, 2011·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Y GowrinathanP M Sabour
Jun 7, 2003·The Journal of Infectious Diseases·Charles HetruJules A Hoffmann
May 29, 2002·The EMBO Journal·Ennio De GregorioBruno Lemaitre
Nov 29, 2002·The EMBO Journal·Petros LigoxygakisJean-Marc Reichhart
Jul 21, 2012·Genome Biology and Evolution·Noah K WhitemanNaomi E Pierce
Jun 17, 2010·Molecular Biology and Evolution·Erin M Hill-Burns, Andrew G Clark
Aug 30, 2011·Molecular Biology and Evolution·Erin S Keebaugh, Todd A Schlenke
Sep 24, 2011·Molecular Biology and Evolution·Alex WongCharles F Aquadro
Oct 18, 2008·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Brian P Lazzaro, Tom J Little
May 12, 2010·Cold Spring Harbor Perspectives in Biology·Charles Hetru, Jules A Hoffmann
Jul 4, 2006·Genes & Development·Shuning ZhangAndrea Page-McCaw

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Phil IrvingCharles Hetru
Annual Review of Immunology
B Lemaitre, Jules A Hoffmann
Proceedings of the National Academy of Sciences of the United States of America
Marie LagueuxJ A Hoffmann
© 2021 Meta ULC. All rights reserved