Genome-wide analysis reveals a highly diverse CD8 T cell response to murine cytomegalovirus

The Journal of Immunology : Official Journal of the American Association of Immunologists
Michael W MunksAnn B Hill

Abstract

Human CMV establishes a lifelong latent infection in the majority of people worldwide. Although most infections are asymptomatic, immunocompetent hosts devote an extraordinary amount of immune resources to virus control. To increase our understanding of CMV immunobiology in an animal model, we used a genomic approach to comprehensively map the C57BL/6 CD8 T cell response to murine CMV (MCMV). Responses to 27 viral proteins were detectable directly ex vivo, the most diverse CD8 T cell response yet described within an individual animal. Twenty-four peptide epitopes were mapped from 18 Ags, which together account for most of the MCMV-specific response. Most Ags were from genes expressed at early times, after viral genes that interfere with Ag presentation are expressed, consistent with the hypothesis that the CD8 T cell response to MCMV is largely driven by cross-presented Ag. Titration of peptide epitopes in a direct ex vivo intracellular cytokine staining assay revealed a wide range of functional avidities, with no obvious correlation between functional avidity and the strength of the response. The immunodominance hierarchy varied only slightly between mice and between experiments. However, H-2(b)-expressing mice with different ...Continue Reading

References

Dec 1, 1996·Journal of Virology·W D RawlinsonB G Barrell
Jun 8, 1999·Annual Review of Immunology·J W Yewdell, J R Bennink
Dec 20, 2000·The Journal of Experimental Medicine·J M den HaanM J Bevan
Jun 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marielle C GoldSteven P Fling
Aug 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Naeem KhanPaul A H Moss
Oct 31, 2002·Nature Immunology·Jonathan W Yewdell, Ann B Hill
Nov 5, 2002·Nature Reviews. Immunology·Matthias J Reddehase
Dec 24, 2002·Nature Immunology·Daniel M AndrewsMariapia A Degli-Esposti
Feb 8, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Urs KarrerPaul Klenerman
Dec 31, 2003·The Journal of Experimental Medicine·Rafaela HoltappelsMatthias J Reddehase
Feb 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gabrielle T BelzWilliam R Heath
Jun 3, 2004·Human Immunology·Matthias J ReddehaseRafaela Holtappels
Jul 28, 2004·Trends in Immunology·Graham PawelecAnders Wikby
Sep 29, 2004·Journal of Virology·Lisa M KattenhornBenedikt M Kessler
Dec 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Naeem KhanPaul A H Moss
Dec 30, 2004·The Journal of Experimental Medicine·David C TscharkeJonathan W Yewdell
Sep 9, 2005·The Journal of Experimental Medicine·Andrew W SylwesterLouis J Picker

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Citations

Jul 15, 2006·Journal of Virology·Rafaela HoltappelsMatthias J Reddehase
May 12, 2007·European Journal of Immunology·Martin F BachmannAnnette Oxenius
Aug 7, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ian R HumphreysMichael Croft
Jul 22, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Glenn R B BantugWilliam J Britt
May 6, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ramon ArensChris A Benedict
Mar 18, 2008·Medical Microbiology and Immunology·Rafaela HoltappelsMatthias J Reddehase
Jul 18, 2009·European Journal of Immunology·Vasileios BekiarisPeter J L Lane
Aug 2, 2012·Viruses·Nicole Torti, Annette Oxenius
Mar 20, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Beatrice BolingerPaul Klenerman
Jan 15, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Vanessa VenturiBrian D Rudd
Nov 4, 2016·Journal of Virology·Jenny W CheRaymond M Welsh
Dec 16, 2017·Nature Immunology·Janko Nikolich-Žugich
Sep 25, 2018·Expert Review of Vaccines·Don Jeffrey DiamondJohn A Zaia
Aug 25, 2006·Journal of Virology·Christian O SimonNatascha K A Grzimek
Mar 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anna LangJanko Nikolich-Zugich
Jan 2, 2007·Reviews in Medical Virology·Richard Kennedy, Gregory A Poland
Oct 18, 2008·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Benno WoelfingThomas Boehm
Jun 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Matthew R PipelingJohn F McDyer
Feb 12, 2010·Annals of the New York Academy of Sciences·Nicolas Blanchard, Nilabh Shastri
Jul 9, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Senta M WaltonAnnette Oxenius
Dec 29, 2007·Immunological Investigations·Shinichiro Fuse, Edward Usherwood
Mar 12, 2008·Medical Microbiology and Immunology·Carmen M Doom, Ann B Hill
Dec 17, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anna LangJanko Nikolich-Zugich
Mar 18, 2011·Journal of Virology·Andrea I LoewendorfPenelope C Kay-Jackson
Mar 5, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lila A FarringtonChristopher M Snyder
Oct 11, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anke RedekerRamon Arens
Jan 13, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·James E McLarenIan R Humphreys
May 21, 2020·Frontiers in Cellular and Infection Microbiology·Mareike EilbrechtMirko Trilling
Jan 22, 2011·Journal of Biomedicine & Biotechnology·Niels A W LemmermannMatthias J Reddehase
Apr 30, 2009·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Melanie WieselAnnette Oxenius
Sep 14, 2012·Medical Microbiology and Immunology·Stefan EbertRafaela Holtappels

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