Genome-wide analysis reveals molecular convergence underlying domestication in 7 bird and mammals

BMC Genomics
Yali HouXuemei Lu

Abstract

In response to ecological niche of domestication, domesticated mammals and birds developed adaptively phenotypic homoplasy in behavior modifications like fearlessness, altered sociability, exploration and cognition, which partly or indirectly result in consequences for economic productivity. Such independent adaptations provide an excellent model to investigate molecular mechanisms and patterns of evolutionary convergence driven by artificial selection. First performing population genomic and brain transcriptional comparisons in 68 wild and domesticated chickens, we revealed evolutionary trajectories, genetic architectures and physiologic bases of adaptively behavioral alterations. To extensively decipher molecular convergence on behavioral changes thanks to domestication, we investigated selection signatures in hundreds of genomes and brain transcriptomes across chicken and 6 other domesticated mammals. Although no shared substitution was detected, a common enrichment of the adaptive mutations in regulatory sequences was observed, presenting significance to drive adaptations. Strong convergent pattern emerged at levels of gene, gene family, pathway and network. Genes implicated in neurotransmission, semaphorin, tectonic protei...Continue Reading

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Datasets Mentioned

BETA
PRJNA202483
PRJNA241474

Methods Mentioned

BETA
RNA-Seq
PCA

Software Mentioned

R
ANNOVAR
SAMtools
TreeMix
LiftOver
Ensembl
GERP
Hiseq2000
TopHat
BCFtools

Related Concepts