Genome-wide approaches to determining origin distribution.

Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology
Jean-Charles Cadoret, Marie-Noëlle Prioleau

Abstract

Genome integrity depends upon a highly co-ordinated process that ensures the exact duplication of the genome at each cell cycle. Genomic mapping of DNA replication starting points in mammals, known as origins of replication, is an important step towards our understanding of how this essential mechanism is regulated throughout complex genomes. Two recent studies carried out in both human and mouse cells have revealed a strong association between replication origins and transcriptional regulatory elements. This strong overlap raises the question of how gene deserts, also lacking replication origins, are properly replicated in conditions where replication is disrupted. It also provides valuable information forward the identification of key regulatory factors of DNA replication initiation. Here, we review what these large-scale mappings of replication origins have brought to our understanding of replication initiation and what are the future prospects.

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Citations

Feb 16, 2010·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Alex ShawDean A Jackson
Sep 3, 2010·Nature Reviews. Genetics·David M Gilbert
Feb 8, 2011·Nature Structural & Molecular Biology·Celina CostasCrisanto Gutierrez
Feb 1, 2011·Briefings in Functional Genomics·Françoise Meisch, Marie-Noëlle Prioleau
Nov 19, 2011·Trends in Genetics : TIG·Michelle DebatisseOlivier Brison
Feb 12, 2014·Biochemistry. Biokhimii︠a︡·Q A Lima NetoM A Fernandez
Sep 22, 2021·Biochemical Society Transactions·Liu Mei, Jeanette Gowen Cook

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