Genome-wide association analysis identifies a meningioma risk locus at 11p15.5.

Neuro-oncology
Elizabeth B ClausJoseph L Wiemels

Abstract

Meningiomas are adult brain tumors originating in the meningeal coverings of the brain and spinal cord, with significant heritable basis. Genome-wide association studies (GWAS) have previously identified only a single risk locus for meningioma, at 10p12.31. To identify a susceptibility locus for meningioma, we conducted a meta-analysis of 2 GWAS, imputed using a merged reference panel from the 1000 Genomes Project and UK10K data, with validation in 2 independent sample series totaling 2138 cases and 12081 controls. We identified a new susceptibility locus for meningioma at 11p15.5 (rs2686876, odds ratio = 1.44, P = 9.86 × 10-9). A number of genes localize to the region of linkage disequilibrium encompassing rs2686876, including RIC8A, which plays a central role in the development of neural crest-derived structures, such as the meninges. This finding advances our understanding of the genetic basis of meningioma development and provides additional support for a polygenic model of meningioma.

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Citations

Feb 24, 2019·Journal of Neuro-oncology·Ivo S MuskensElizabeth B Claus
Jun 28, 2019·Neuro-oncology·Ivo S MuskensJoseph L Wiemels
Jul 14, 2019·Neuro-oncology·Quinn T OstromMelissa L Bondy
Jan 24, 2019·Scientific Reports·Hannah TakahashiRichard S Houlston
Jul 7, 2020·Neuro-oncology Practice·Elizabeth B ClausLisa Calvocoressi
Nov 24, 2020·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Jon Foss-SkiftesvikJonas Bybjerg-Grauholm
Nov 25, 2021·Current Neurology and Neuroscience Reports·Quinn T OstromJill S Barnholtz-Sloan

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