Genome-wide association analysis of juvenile idiopathic arthritis identifies a new susceptibility locus at chromosomal region 3q13.

Arthritis and Rheumatism
S D ThompsonDavid N Glass

Abstract

In a genome-wide association study of Caucasian patients with juvenile idiopathic arthritis (JIA), we have previously described findings limited to autoimmunity loci shared by JIA and other diseases. The present study was undertaken to identify novel JIA-predisposing loci using genome-wide approaches. The discovery cohort consisted of Caucasian JIA cases (n = 814) and local controls (n = 658) genotyped on the Affymetrix Genome-Wide SNP 6.0 Array, along with 2,400 out-of-study controls. In a replication study, we genotyped 10 single-nucleotide polymorphisms (SNPs) in 1,744 cases and 7,010 controls from the US and Europe. Analysis within the discovery cohort provided evidence of associations at 3q13 within C3orf1 and near CD80 (rs4688011) (odds ratio [OR] 1.37, P = 1.88 × 10(-6) ) and at 10q21 near JMJD1C (rs647989 [OR 1.59, P = 6.1 × 10(-8) ], rs12411988 [OR 1.57, P = 1.16 × 10(-7) ], and rs10995450 [OR 1.31, P = 6.74 × 10(-5) ]). Meta-analysis provided further evidence of association for these 4 SNPs (P = 3.6 × 10(-7) for rs4688011, P = 4.33 × 10(-5) for rs6479891, P = 2.71 × 10(-5) for rs12411988, and P = 5.39 × 10(-5) for rs10995450). Gene expression data on 68 JIA cases and 23 local controls showed cis expression quantit...Continue Reading

References

May 1, 1975·Arthritis and Rheumatism·D B SullivanR E Petty
Oct 8, 1999·Arthritis and Rheumatism·K J MurrayD N Glass
Nov 11, 1999·Arthritis and Rheumatism·D N Glass, E H Giannini
May 29, 2007·Arthritis and Rheumatism·R K SaurenmannE D Silverman
Jul 7, 2007·Current Biology : CB·Aleixo M MuiseDaniela Rotin
Sep 18, 2007·Nature Genetics·Anna L DixonWilliam O C Cookson
Jun 26, 2008·Arthritis and Rheumatism·Edward M BehrensHakon Hakonarson
Jul 9, 2008·American Journal of Human Genetics·Alkes L PriceDavid Reich
Jan 1, 2009·Arthritis and Rheumatism·Anne HinksUNKNOWN British Society of Paediatric and Adolescent Rheumatology Study Group
Jul 1, 2009·Arthritis and Rheumatism·Michael G BarnesRobert A Colbert
Aug 14, 2009·Annals of the Rheumatic Diseases·Anne HinksWendy Thomson
Jan 12, 2010·Nature Genetics·UNKNOWN Australo-Anglo-American Spondyloarthritis Consortium (TASC)Matthew A Brown
Mar 2, 2010·Nature Genetics·Patrick C A DuboisDavid A van Heel
Mar 2, 2010·Arthritis and Rheumatism·Jill A HollenbachDavid N Glass
Oct 19, 2010·Nature Genetics·Philip E StuartJames T Elder
Nov 12, 2010·Annals of the Rheumatic Diseases·Gisela OrozcoAnne Barton
Dec 21, 2010·American Journal of Human Genetics·Jian YangPeter M Visscher
Mar 8, 2011·American Journal of Human Genetics·Sang Hong LeePeter M Visscher
Apr 5, 2011·Biochemical and Biophysical Research Communications·Wenzhan MaWei Wang

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Citations

Nov 17, 2012·Pediatric Rheumatology Online Journal·Justine A EllisJane E Munro
Jun 3, 2014·Arthritis Research & Therapy·Adam StevensRachelle P Donn
Jun 30, 2014·Best Practice & Research. Clinical Rheumatology·Michael J OmbrelloDaniel L Kastner
Feb 22, 2014·Autoimmunity·Dimitry A ChistiakovAlexander A Baranov
Mar 29, 2014·International Journal of Rheumatic Diseases·Surjit SinghDebashish Danda
Mar 24, 2016·BMC Medical Genetics·Terri H FinkelHakon Hakonarson
Nov 12, 2014·Clinical Reviews in Allergy & Immunology·Donato RiganteSusanna Esposito
Sep 10, 2014·Arthritis & Rheumatology·Simon W M EngUNKNOWN REACCH OUT and BBOP Research Consortia
Dec 30, 2014·Pediatric Rheumatology Online Journal·Rachel C Chiaroni-ClarkeJustine A Ellis
Sep 10, 2016·American Journal of Respiratory and Critical Care Medicine·Berta AlmogueraHakon Hakonarson
Jul 19, 2017·Arthritis & Rheumatology·Laura A McIntoshSusan D Thompson
Jul 11, 2014·Current Opinion in Rheumatology·Halima MoncrieffeSusan D Thompson
Dec 21, 2019·Journal of Bioinformatics and Computational Biology·Farhad MalekiAnthony J Kusalik
Oct 11, 2017·Molecular Medicine Reports·Maria I ZervouGeorge N Goulielmos
Jun 25, 2019·Frontiers in Medicine·Shi Huan TaySalvatore Albani
May 19, 2020·Human Molecular Genetics·James DingGisela Orozco
Jul 25, 2014·Annals of the Rheumatic Diseases·T H C M ReinardsM W Schilham
Nov 23, 2021·The Journal of Gene Medicine·Ivan Yurievich BakutenkoNadezhda Ivanovna Ryabokon

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