Genome-wide association analysis reveals novel loci for hypoxia adaptability in Tibetan chicken

Animal Genetics
S Y JiangC Wu

Abstract

The Tibetan chicken (TBC), an indigenous chicken breed of the Tibetan Plateau, has adapted to its hypoxic, high-altitude environment over hundreds of years. The objective of this study was to identify the polymorphisms and genes associated with adaptation to hypoxia in this chicken breed. In the present study, samples were collected during days 18-21 of the incubation period from both surviving chicks and dead embryos, all of which were hatched under hypoxic conditions. A genome-wide association study was conducted using the Illumina iSelect 60K SNP array with a case-control design, in which the case group consisted of the dead chicken embryos (n = 54) and controls were the surviving chicks (n = 82). Four significant SNPs were detected at the genome-wide level (P < 0.05), and the results indicated that fork head box G1 (FOXG1) was the main candidate gene. The lead SNP NC_006092.4:g.33368893T>C was confirmed with a polymerase chain reaction-restriction fragment length polymorphism analysis of 122 cases and 212 controls. A chi-square test showed a significant association between NC_006092.4:g.33368893T>C and hatchability under hypoxic conditions (P < 0.01). Our results revealed novel polymorphisms and a candidate gene associated ...Continue Reading

References

Feb 18, 2006·Science in China. Series C, Life Sciences·Xiao GouChangxin Wu
Feb 9, 2010·American Journal of Human Genetics·Timothy Thornton, Mary Sara McPeek
Jun 2, 2011·BMC Genomics·Martien A M GroenenHans H Cheng
Sep 25, 2012·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·C LiuN Li
Jul 6, 2014·EvoDevo·Jens H FritzenwankerChristopher J Lowe
Mar 20, 2015·Molecular Biology and Evolution·Ming-Shan WangYa-Ping Zhang
Sep 10, 2016·Animal Genetics·Chunhua QinShengli Zhang

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