Oct 30, 2018

Genome-wide association and functional studies identify 46 novel loci for alcohol consumption and suggest common genetic mechanisms with neuropsychiatric disorders

BioRxiv : the Preprint Server for Biology
Evangelos EvangelouPaul Elliott

Abstract

Excessive alcohol consumption is one of the main causes of death and disability worldwide. Alcohol consumption is a heritable complex trait. We conducted a genome-wide association study (GWAS) of alcohol use in ~480,000 people of European descent to decipher the genetic architecture of alcohol intake. We identified 46 novel, common loci, and investigated their potential functional significance using magnetic resonance imaging data, gene expression and behavioral studies in Drosophila. Our results identify new genetic pathways associated with alcohol consumption and suggest common genetic mechanisms with several neuropsychiatric disorders including schizophrenia.

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Mentioned in this Paper

Genome-Wide Association Study
Study
Biochemical Pathway
Magnetic Resonance Imaging
Schizophrenia
Cessation of Life
Drosophila
Persons
Gene Expression
Genetic Activator

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