Genome wide association and gene enrichment analysis reveal membrane anchoring and structural proteins associated with meat quality in beef

BMC Genomics
Joel D Leal-GutiérrezRaluca G Mateescu

Abstract

Meat quality related phenotypes are difficult and expensive to measure and predict but are ideal candidates for genomic selection if genetic markers that account for a worthwhile proportion of the phenotypic variation can be identified. The objectives of this study were: 1) to perform genome wide association analyses for Warner-Bratzler Shear Force (WBSF), marbling, cooking loss, tenderness, juiciness, connective tissue and flavor; 2) to determine enriched pathways present in each genome wide association analysis; and 3) to identify potential candidate genes with multiple quantitative trait loci (QTL) associated with meat quality. The WBSF, marbling and cooking loss traits were measured in longissimus dorsi muscle from 672 steers. Out of these, 495 animals were used to measure tenderness, juiciness, connective tissue and flavor by a sensory panel. All animals were genotyped for 221,077 markers and included in a genome wide association analysis. A total number of 68 genomic regions covering 52 genes were identified using the whole genome association approach; 48% of these genes encode transmembrane proteins or membrane associated molecules. Two enrichment analysis were performed: a tissue restricted gene enrichment applying a co...Continue Reading

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Citations

Feb 1, 2020·BMC Genomics·Joel D Leal-GutiérrezRaluca G Mateescu
Aug 6, 2020·Animals : an Open Access Journal From MDPI·Maria Giuseppina StrillacciGuillermo Martinez-Velazquez
Apr 6, 2021·Frontiers in Genetics·Fernanda M RezendeRaluca G Mateescu

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Methods Mentioned

BETA
GTPase
glycosylation

Software Mentioned

Ex
Ensembl
- Genomics
JMP genomics
Prosite
DAVID Bioinformatic Resources
Genetics Q - K
TMHMM
Phobius
SignalP

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