Genome-wide association mapping identifies multiple loci for a canine SLE-related disease complex.

Nature Genetics
M WilbeKerstin Lindblad-Toh

Abstract

The unique canine breed structure makes dogs an excellent model for studying genetic diseases. Within a dog breed, linkage disequilibrium is extensive, enabling genome-wide association (GWA) with only around 15,000 SNPs and fewer individuals than in human studies. Incidences of specific diseases are elevated in different breeds, indicating that a few genetic risk factors might have accumulated through drift or selective breeding. In this study, a GWA study with 81 affected dogs (cases) and 57 controls from the Nova Scotia duck tolling retriever breed identified five loci associated with a canine systemic lupus erythematosus (SLE)-related disease complex that includes both antinuclear antibody (ANA)-positive immune-mediated rheumatic disease (IMRD) and steroid-responsive meningitis-arteritis (SRMA). Fine mapping with twice as many dogs validated these loci. Our results indicate that the homogeneity of strong genetic risk factors within dog breeds allows multigenic disorders to be mapped with fewer than 100 cases and 100 controls, making dogs an excellent model in which to identify pathways involved in human complex diseases.

References

Nov 1, 1982·Arthritis and Rheumatism·E M TanR J Winchester
Jun 18, 1997·Biochemical and Biophysical Research Communications·D Guerini
May 23, 2000·European Journal of Immunology·S HanT Mustelin
May 15, 2004·Arthritis Research & Therapy·Nancy J OlsenThomas M Aune
Nov 17, 2004·Genome Research·Nathan B SutterElaine A Ostrander
Dec 13, 2005·Nature·Kerstin Lindblad-TohEric S Lander
Oct 14, 2006·European Journal of Immunology·Edgar SerflingEdgar Schmitt
Nov 24, 2006·Veterinary Clinical Pathology·Helene Hansson-HamlinGunilla Trowald-Wigh
Jan 24, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Vasileios C KyttarisGeorge C Tsokos
Oct 2, 2007·Nature Genetics·Elinor K KarlssonKerstin Lindblad-Toh
Dec 14, 2007·Autoimmunity·Sharon A Chung, Lindsey A Criswell
Jan 22, 2008·Nature Genetics·Sergey V KozyrevMarta E Alarcón-Riquelme
Apr 26, 2008·PLoS Genetics·Michelle M A FernandoJohn D Rioux
May 2, 2008·International Immunology·Connie L SommersLawrence E Samelson
Aug 21, 2008·Nature Reviews. Genetics·Elinor K Karlsson, Kerstin Lindblad-Toh
Sep 13, 2008·Science·Cord DrögemüllerTosso Leeb
Apr 1, 2009·Acta Veterinaria Scandinavica·Helene Hansson-Hamlin, Inger Lilliehöök
Jul 29, 2009·Immunogenetics·Maria WilbeGöran Andersson

❮ Previous
Next ❯

Citations

Nov 9, 2011·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Keiko MiyaderaGustavo D Aguirre
Nov 1, 2011·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Kari J EkenstedtJames R Mickelson
Nov 11, 2011·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Cathryn Mellersh
Nov 15, 2011·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Bethany J Wilson, Claire M Wade
Nov 15, 2011·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Thomas DerrienChristophe Hitte
Nov 23, 2011·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Kate L TsaiLeigh Anne Clark
Dec 8, 2011·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Hille FietenJan Rothuizen
Jan 11, 2012·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Heidi G Parker
Jan 18, 2013·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Meryl P LittmanPaula S Henthorn
Aug 27, 2010·Nature·David Cyranoski
Oct 17, 2012·Nature Reviews. Rheumatology·Nan ShenPaul-Peter Tak
Aug 17, 2012·The New England Journal of Medicine·Elaine A Ostrander
Aug 24, 2011·The Journal of Heredity·Renee M BarberMatthew J Huentelman
Apr 15, 2011·Parasites & Vectors·Michael J Day
Apr 15, 2011·Parasites & Vectors·Michael J Day
Aug 11, 2011·PLoS Genetics·Eija H SeppäläHannes Lohi
Jun 1, 2011·PloS One·Theresa-Bernadette MausbergTosso Leeb
Mar 15, 2014·Immunogenetics·Jonathan MasseyLorna J Kennedy
Jan 1, 2011·Genetics Research International·Jeremy R Shearman, Alan N Wilton
Oct 17, 2013·The Veterinary Record·H Hansson-Hamlin, I Lilliehöök
Nov 26, 2010·International Immunopharmacology·O A GardenF Cunningham
Dec 30, 2015·Immunogenetics·Steven G FriedenbergKathryn M Meurs
Jan 4, 2013·Reproduction in Domestic Animals = Zuchthygiene·V N Meyers-Wallen
Jan 27, 2011·The Journal of Small Animal Practice·N T Whitley, M J Day
Apr 22, 2015·BMC Veterinary Research·Anna TauroClare Rusbridge
Mar 12, 2015·Veterinary Immunology and Immunopathology·Ashley N Hartley, Rick L Tarleton
Mar 31, 2015·Topics in Companion Animal Medicine·Alisdair M Boag, Brian Catchpole
May 1, 2016·Mammalian Genome : Official Journal of the International Mammalian Genome Society·S G Friedenberg, K M Meurs

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.